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Cellosaurus ALL-PO (CVCL_1069)

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Cell line name ALL-PO
Synonyms ALLPO; AllPO
Accession CVCL_1069
Resource Identification Initiative To cite this cell line use: ALL-PO (RRID:CVCL_1069)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Sequence variations KMT2A-AFF1 (MLL-AFF1; ALL-1/AF4) gene fusion (PubMed=14671638).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.07
East Asian, North2.2
East Asian, South1.8
South Asian1.45
European, North52.99
European, South41.49
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23) KMT2A rearranged (NCIt: C80342)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 4M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ICLC

Markers:
AmelogeninX
CSF1PO10,11
D5S81811,12
D7S8209,11
D13S31711,12
D16S53913
D21S1129,30
TH016,7
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=9444945; DOI=10.1016/S0145-2126(97)00092-1
Gobbi A., Di Berardino C., Scanziani E., Garofalo A., Rivolta A., Fontana G., Rambaldi A., Giavazzi R., Biondi A.
A human acute lymphoblastic leukemia line with the T(4;11) translocation as a model of minimal residual disease in SCID mice.
Leuk. Res. 21:1107-1114(1997)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ICLC; HTL01003
Cell line databases/resources CLDB; cl5399
CCLE; ALLPO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00211
Cosmic-CLP; 910944
DepMap; ACH-002209
LINCS_LDP; LCL-1043
Ontologies CLO; CLO_0001705
Chemistry resources ChEMBL-Cells; CHEMBL3308227
ChEMBL-Targets; CHEMBL2366294
GDSC; 910944
PharmacoDB; ALLPO_58_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669596
Other Wikidata; Q54749226
Polymorphism and mutation databases Cosmic; 910944
IARC_TP53; 21173
Entry history
Entry creation04-Apr-2012
Last entry updated19-Dec-2019
Version number25