Cellosaurus AM-38 (CVCL_1070)

Cell line name AM-38
Synonyms AM38; AM
Accession CVCL_1070
Resource Identification Initiative To cite this cell line use: AM-38 (RRID:CVCL_1070)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 72 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S3178
D16S53911,13
D18S5113
D19S43314
D21S1130
D2S133819,24
D3S135815
D5S81812,13
D7S82012
D8S117913,14
FGA23,25
Penta D13
Penta E5,18
TH017
TPOX11
vWA17,18 (Cosmic-CLP)
17 (JCRB; PubMed=25877200)
Publications

PubMed=8145054; DOI=10.1007/BF01050213
Izumu I., Mineura K., Watanabe K., Kowada M.
Characterization and chemosensitivity of two cell lines derived from human glioblastomas.
J. Neurooncol. 17:111-121(1993)

PubMed=7947440
Izumi I., Mineura K., Watanabe K., Kowada M.
Establishment of the two glioma cell lines: YH and AM.
Hum. Cell 7:101-105(1994)

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x
Saigusa K., Hashimoto N., Tsuda H., Yokoi S., Maruno M., Yoshimine T., Aoyagi M., Ohno K., Imoto I., Inazawa J.
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer Sci. 96:676-683(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections IFO; IFO50492
Cell line databases/resources CCLE; AM38_CENTRAL_NERVOUS_SYSTEM
CGH-DB; 139-1
Cosmic-CLP; 910933
GDSC; 910933
LINCS_LDP; LCL-1366
Biological sample resources BioSample; SAMN03470932
Chemistry resources ChEMBL-Cells; CHEMBL3308829
ChEMBL-Targets; CHEMBL2366192
Gene expression databases GEO; GSM326247
GEO; GSM886866
GEO; GSM887931
GEO; GSM1669598
Polymorphism and mutation databases Cosmic; 685873
Cosmic; 910933
Cosmic; 1746962
Cosmic; 2302334
Cosmic; 2367507
Cosmic; 2516013