Cellosaurus AML-193 (CVCL_1071)

Cell line name AML-193
Synonyms AML193
Accession CVCL_1071
Resource Identification Initiative To cite this cell line use: AML-193 (RRID:CVCL_1071)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Characteristics: CSF2 and IL3 dependent.
Doubling time: 65 hours (PubMed=25984343); ~50-60 hours (DSMZ).
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Childhood acute myeloid leukemia (NCIt: C9160)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_8441 (SR-91)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D13S31712
D16S53912
D5S8189,13
D7S8209,12
TH017,9
TPOX8,9
vWA15,17
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=AML-193
http://www.infarktforschung.de/macrophages_cell_lines.html
Publications

PubMed=3496132
Lange B., Valtieri M., Santoli D., Caracciolo D., Mavilio F., Gemperlein I., Griffin C., Emanuel B.S., Finan J., Nowell P.C., Rovera G.
Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.
Blood 70:192-199(1987)

PubMed=2656885; DOI=10.1002/stem.5530070202
Ihle J.N., Askew D.
Origins and properties of hematopoietic growth factor-dependent cell lines.
Int. J. Cell Cloning 7:68-91(1989)

PubMed=2015403
Valtieri M., Boccoli G., Testa U., Barletta C., Peschle C.
Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF.
Blood 77:1804-1812(1991)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

Cross-references
Cell line collections ATCC; CRL-9589
ATCC; HTB-188 - Discontinued
BCRJ; 0040 - Discontinued
DSMZ; ACC-549
Cell line databases/resources CLDB; cl272
CCLE; AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Ontologies CLO; CLO_0001718
Biological sample resources BioSample; SAMN01821616
BioSample; SAMN03471219
Gene expression databases GEO; GSM886867
GEO; GSM887932
Polymorphism and mutation databases Cosmic; 724816
Cosmic; 787420
Cosmic; 949089
Cosmic; 975238
Cosmic; 1012057
Cosmic; 1281305
Cosmic; 2306199