ID   AML-193
AC   CVCL_1071
SY   AML193
DR   BTO; BTO:0006203
DR   CLO; CLO_0001718
DR   CLDB; cl272
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CRL-9589
DR   ATCC; HTB-188
DR   BCRJ; 0040
DR   BioSample; SAMN01821616
DR   BioSample; SAMN03471219
DR   BioSample; SAMN10987604
DR   CCLE; AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   CCRID; 3131C0001000700207
DR   Cell_Model_Passport; SIDM01525
DR   Cosmic; 724816
DR   Cosmic; 787420
DR   Cosmic; 949089
DR   Cosmic; 975238
DR   Cosmic; 1012057
DR   Cosmic; 1281305
DR   Cosmic; 2306199
DR   Cosmic; 2750853
DR   DepMap; ACH-000557
DR   DSMZ; ACC-549
DR   GEO; GSM886867
DR   GEO; GSM887932
DR   IARC_TP53; 27144
DR   LiGeA; CCLE_497
DR   Lonza; 1685
DR   PharmacoDB; AML193_61_2019
DR   Progenetix; CVCL_1071
DR   Wikidata; Q54749799
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2015403;
RX   PubMed=2656885;
RX   PubMed=3496132;
RX   PubMed=12068308;
RX   PubMed=16408098;
RX   PubMed=20164919;
RX   PubMed=21989985;
RX   PubMed=22460905;
RX   PubMed=25984343;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=AML-193
WW   http://www.infarktforschung.de/macrophages_cell_lines.html
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Characteristics: CSF2 and IL3 dependent.
CC   Doubling time: 65 hours (PubMed=25984343); ~50-60 hours (DSMZ).
CC   Sequence variation: Mutation; HGNC; 25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (PubMed=21989985; CCLE).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (PubMed=12068308; CCLE).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.993+2T>G; ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=65.28%; Native American=0%; East Asian, North=3.56%; East Asian, South=0%; South Asian=0%; European, North=14.42%; European, South=16.74% (PubMed=30894373).
CC   Discontinued: BCRJ; 0040; probable.
CC   Discontinued: ATCC; HTB-188; true.
ST   Source(s): ATCC; DSMZ
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 12
ST   D16S539: 12
ST   D5S818: 9,13
ST   D7S820: 9,12
ST   TH01: 7,9
ST   TPOX: 8,9
ST   vWA: 15,17
DI   NCIt; C9160; Childhood acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 29
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=2015403; DOI=10.1182/blood.V77.8.1804.1804;
RA   Valtieri M., Boccoli G., Testa U., Barletta C., Peschle C.;
RT   "Two-step differentiation of AML-193 leukemic line: terminal
RT   maturation is induced by positive interaction of retinoic acid with
RT   granulocyte colony-stimulating factor (CSF) and vitamin D3 with
RT   monocyte CSF.";
RL   Blood 77:1804-1812(1991).
//
RX   PubMed=2656885; DOI=10.1002/stem.5530070202;
RA   Ihle J.N., Askew D.;
RT   "Origins and properties of hematopoietic growth factor-dependent cell
RT   lines.";
RL   Int. J. Cell Cloning 7:68-91(1989).
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RX   PubMed=3496132; DOI=10.1182/blood.V70.1.192.192;
RA   Lange B., Valtieri M., Santoli D., Caracciolo D., Mavilio F.,
RA   Gemperlein I., Griffin C., Emanuel B.S., Finan J., Nowell P.C.,
RA   Rovera G.;
RT   "Growth factor requirements of childhood acute leukemia: establishment
RT   of GM-CSF-dependent cell lines.";
RL   Blood 70:192-199(1987).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.;
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=21989985; DOI=10.1182/blood-2011-05-356204;
RA   Li M., Collins R., Jiao Y., Ouillette P., Bixby D., Erba H.,
RA   Vogelstein B., Kinzler K.W., Papadopoulos N., Malek S.N.;
RT   "Somatic mutations in the transcriptional corepressor gene BCORL1 in
RT   adult acute myelogenous leukemia.";
RL   Blood 118:5914-5917(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//