Home  |  Contact

Cellosaurus ARH-77 (CVCL_1072)

[Text version]

Cell line name ARH-77
Synonyms ARH 77; ARH77
Accession CVCL_1072
Resource Identification Initiative To cite this cell line use: ARH-77 (RRID:CVCL_1072)
Comments Problematic cell line: Misidentified. Originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line (PubMed=7579375; PubMed=10516762).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 110.4 hours (PubMed=566614); ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: AHR 77; Occasionally.
Sequence variations Homozygous for TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.24
Native American0.38
East Asian, North0
East Asian, South2.18
South Asian8.63
European, North25.32
European, South61.25
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8119 (HMy.2 B)
Sex of cell Female
Age at sampling 33Y
Category Transformed cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; ECACC

Markers:
AmelogeninX
CSF1PO6,10
D5S81810,13
D7S8207,12
D13S31711,13
D16S5399,13
TH018,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=3301
Publications

PubMed=566614
Burk K.H., Drewinko B., Trujillo J.M., Ahearn M.J.
Establishment of a human plasma cell line in vitro.
Cancer Res. 38:2508-2513(1978)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Nakano A., Harada T., Morikawa S., Kato Y.
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=7579375; DOI=10.1182/blood.V86.10.4001.bloodjournal86104001
Pellat-Deceunynck C., Amiot M., Bataille R., Van Riet I., Van Camp B., Omede P., Boccadoro M.
Human myeloma cell lines as a tool for studying the biology of multiple myeloma: a reappraisal 18 years after.
Blood 86:4001-4002(1995)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=10516762; DOI=10.1038/sj.leu.2401510
Drexler H.G., Dirks W.G., MacLeod R.A.F.
False human hematopoietic cell lines: cross-contaminations and misinterpretations.
Leukemia 13:1601-1607(1999)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=14555701
Shammas M.A., Shmookler Reis R.J., Akiyama M., Koley H., Chauhan D., Hideshima T., Goyal R.K., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Mol. Cancer Ther. 2:825-833(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-1621
BCRC; 60385
CCTCC; GDC0218
DSMZ; ACC-512
ECACC; 88121201
Cell line databases/resources CLDB; cl285
CCLE; ARH77_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3142C0001000001721
Cell_Model_Passport; SIDM00900
Cosmic-CLP; 906765
DepMap; ACH-002210
IGRhCellID; ARH77
LINCS_LDP; LCL-2041
Lonza; 593
Ontologies BTO; BTO:0002992
CLO; CLO_0001744
CLO; CLO_0001745
EFO; EFO_0002111
Biological sample resources BioSample; SAMN03471407
Chemistry resources ChEMBL-Cells; CHEMBL3308536
ChEMBL-Targets; CHEMBL2366241
GDSC; 906765
PharmacoDB; ARH77_64_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1374393
GEO; GSM1669601
Other Wikidata; Q54750440
Polymorphism and mutation databases Cosmic; 759914
Cosmic; 886086
Cosmic; 888020
Cosmic; 906765
Cosmic; 919148
Cosmic; 999792
IARC_TP53; 21176
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number29