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Cellosaurus BALL-1 (CVCL_1075)

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Cell line name BALL-1
Synonyms Ball-1; Ball 1; BALL1; B-cell Acute Lymphoblastic Leukemia-1
Accession CVCL_1075
Resource Identification Initiative To cite this cell line use: BALL-1 (RRID:CVCL_1075)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: 80 hours (in RPMI-1640 + 20% HCS), 66 hours (in RPMI-1640 + 20% FCS) (PubMed=195075); ~48-72 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Homozygous for TP53 p.Asp281Gly (c.842A>G) (ClinVar=VCV000141141) (PubMed=15901131; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North81.09
East Asian, South18.9
South Asian0
European, North0
European, South0
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): CCRID; Cosmic-CLP; DSMZ; JCRB; RCB; TKG

AmelogeninX (JCRB; TKG)
D5S81810,12,13 (RCB)
10,13 (CCRID; Cosmic-CLP; JCRB; TKG)

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/

PubMed=195075; DOI=10.1093/jnci/59.1.93
Hiraki S., Miyoshi I., Masuji H., Kubonishi I., Matsuda Y.
Establishment of an Epstein-Barr virus-determined nuclear antigen-negative human B-cell line from acute lymphoblastic leukemia.
J. Natl. Cancer Inst. 59:93-94(1977)

PubMed=197412; DOI=10.1038/267843a0
Miyoshi I., Hiraki S., Tsubota T., Kubonishi I., Matsuda Y., Nakayama T., Kishimoto H., Kimura I., Masuji H.
Human B cell, T cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias.
Nature 267:843-844(1977)

Nakamura K.
Studies on human leukemic B-cell line, Part I. Establishment and characterization of human leukemic B-cell line (BALL-1).
Okayama Igakkai Zasshi 92:763-773(1980)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=8156010; DOI=10.1159/000236736
Yoshida N., Ueno M., Saita N., Hirashima M.
A B cell lymphoma line, BALL-1 stimulates T cells to produce a unique eosinophil chemotactic factor.
Int. Arch. Allergy Immunol. 104:9-11(1994)

Matsuo Y., Okochi A., Ariyasu T., Iimura E., Ohno T.
Identification of cell lines with variable numbers of tandem repeat (VNTR) amplified by polymerase chain reaction.
Tissue Cult. Res. Commun. 15:211-219(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections DSMZ; ACC-742
KCB; KCB 94007YJ
RCB; RCB0256
RCB; RCB1882
TKG; TKG 0467
CCRID; 3153C0001000000225
Cell_Model_Passport; SIDM00287
Cosmic-CLP; 910705
DepMap; ACH-002211
Ontologies BTO; BTO:0001148
CLO; CLO_0037300
CLO; CLO_0051004
CLO; CLO_0051005
Biological sample resources BioSample; SAMN03471059
BioSample; SAMN03472350
Chemistry resources ChEMBL-Cells; CHEMBL3308839
ChEMBL-Targets; CHEMBL2366269
GDSC; 910705
PharmacoDB; BALL1_73_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827223
GEO; GSM1669606
Other Wikidata; Q54753112
Polymorphism and mutation databases Cosmic; 910705
Cosmic; 919134
Cosmic; 999755
Cosmic; 999762
Cosmic; 1150902
IARC_TP53; 21184
Progenetix; CVCL_1075
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number30