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Cellosaurus BB49-HNC (CVCL_1077)

[Text version]

Cell line name BB49-HNC
Synonyms BB49 HNC; BB49HNC; BB49-SCCHN
Accession CVCL_1077
Resource Identification Initiative To cite this cell line use: BB49-HNC (RRID:CVCL_1077)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
From: Ludwig Institute for Cancer Research, Brussels Branch; Brussels; Belgium.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.55
East Asian, North0.98
East Asian, South0
South Asian2.14
European, North57.6
European, South38.06
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_VU51 ! BB49-EBV
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP


Run an STR similarity search on this cell line

PubMed=9271594; DOI=10.1084/jem.186.5.785
Mandruzzato S., Brasseur F., Andry G., Boon T., van der Bruggen P.
A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.
J. Exp. Med. 186:785-793(1997)

Zammatteo N., Lockman L., Brasseur F., De Plaen E., Lurquin C., Lobert P.-E., Hamels S., Boon T., Remacle J.
DNA microarray to monitor the expression of MAGE-A genes.
Clin. Chem. 48:25-34(2002)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line databases/resources CCLE; BB49HNC_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00174
Cosmic-CLP; 753532
DepMap; ACH-002213
GDSC; 753532
Chemistry resources ChEMBL-Cells; CHEMBL3308282
ChEMBL-Targets; CHEMBL2366295
PharmacoDB; BB49HNC_75_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669608
Other Wikidata; Q54795063
Polymorphism and mutation databases Cosmic; 753532
Cosmic; 2116768
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22