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Cellosaurus BC-1 (CVCL_1079)

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Cell line name BC-1
Synonyms BC1
Accession CVCL_1079
Resource Identification Initiative To cite this cell line use: BC-1 (RRID:CVCL_1079)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~35-48 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Ascites.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.64
East Asian, North0.52
East Asian, South0
South Asian0.4
European, North67.92
European, South30.53
Disease Primary effusion lymphoma (NCIt: C6915)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_4221 ! HBL-6
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811,12
D7S82011
D13S3178
D16S53912,13
TH019.3
TPOX8,9
vWA16,20

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=BC-1
Publications

PubMed=7670109
Cesarman E., Moore P.S., Rao P.H., Inghirami G., Knowles D.M., Chang Y.
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.
Blood 86:2708-2714(1995)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005
Fan W., Bubman D., Chadburn A., Harrington W.J. Jr., Cesarman E., Knowles D.M.
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:E32-E39(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-2230
DSMZ; ACC-677
Cell line databases/resources CCLE; BC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00896
Cosmic-CLP; 910919
DepMap; ACH-002214
IGRhCellID; BC1
LINCS_LDP; LCL-1956
Lonza; 914
Ontologies BTO; BTO:0002720
CLO; CLO_0001887
EFO; EFO_0002044
Biological sample resources BioSample; SAMN03471843
BioSample; SAMN03473432
BioSamples; SAMEA365796
BioSamples; SAMEA365808
Chemistry resources ChEMBL-Cells; CHEMBL3307907
ChEMBL-Targets; CHEMBL614277
GDSC; 910919
PharmacoDB; BC1_77_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM33136
GEO; GSM38792
GEO; GSM38793
GEO; GSM634731
GEO; GSM710417
GEO; GSM710433
GEO; GSM1669610
Other Wikidata; Q54795185
Polymorphism and mutation databases Cosmic; 687602
Cosmic; 910919
Cosmic; 1515186
Cosmic; 1588556
Entry history
Entry creation04-Apr-2012
Last entry updated19-Dec-2019
Version number26