Cellosaurus BC-3 (CVCL_1080)

Cell line name BC-3
Synonyms BC3
Accession CVCL_1080
Resource Identification Initiative To cite this cell line use: BC-3 (RRID:CVCL_1080)
Comments Doubling time: ~50-60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Disease Primary effusion lymphoma (NCIt: C6915)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D13S31711
D16S53912
D5S81811,12
D7S82010,12
TH016,9
TPOX8,11
vWA14,18
Publications

PubMed=8839859
Arvanitakis L., Mesri E.A., Nador R.G., Said J.W., Asch A.S., Knowles D.M., Cesarman E.
Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus.
Blood 88:2648-2654(1996)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005
Fan W., Bubman D., Chadburn A., Harrington W.J. Jr., Cesarman E., Knowles D.M.
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:E32-E39(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-2277
DSMZ; ACC-679
Cell line databases/resources Cosmic-CLP; 910918
GDSC; 910918
IGRhCellID; BC3
LINCS_LDP; LCL-1948
Ontologies BTO; BTO:0002722
CLO; CLO_0001891
EFO; EFO_0002046
Biological sample resources BioSample; SAMN03472835
BioSamples; SAMEA365848
BioSamples; SAMEA365859
Chemistry resources ChEMBL-Cells; CHEMBL3308890
ChEMBL-Targets; CHEMBL2366371
Gene expression databases GEO; GSM38796
GEO; GSM38797
GEO; GSM634733
GEO; GSM710419
GEO; GSM710435
GEO; GSM1669611
Polymorphism and mutation databases Cosmic; 687836
Cosmic; 910918
Cosmic; 1238077
Cosmic; 1515188
Cosmic; 1588558