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Cellosaurus BE-13 (CVCL_1081)

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Cell line name BE-13
Synonyms Be-13; BE13; Be13
Accession CVCL_1081
Resource Identification Initiative To cite this cell line use: BE-13 (RRID:CVCL_1081)
Comments Problematic cell line: Contaminated. Shown to be a Peer derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 11 year old patient with T-ALL.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00178.
Doubling time: ~40-60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion NKX2.5-BCL11B (PubMed=14500364).
Gene fusion NUP214-ABL1 (from parent cell line).
NOTCH1 p.Leu1600Pro (c.4799T>C) (PubMed=22675565).
Heterozygous for TP53 p.Tyr163Cys (c.488A>G) (ClinVar=VCV000127814) (PubMed=22675565; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.02
Native American1.38
East Asian, North0
East Asian, South1.18
South Asian10.89
European, North13.65
European, South69.88
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1913 (Peer)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO12
D5S81812
D7S82010,12
D13S31711,14
D16S5398,13
TH017,8
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4
Rabinowitz R., Weinstock J., Margalioth E.J., Ben-Bassat H., Schlesinger M.
Antigens specific for human T-lymphocytes detected by xenoantisera to HD-MAR cells: their differential expression on various T-cell lines.
Hum. Immunol. 4:219-228(1982)

PubMed=6331881
Galili U., Peleg A., Milner Y., Galili N.
Be13, a human T-leukemia cell line highly sensitive to dexamethasone-induced cytolysis.
Cancer Res. 44:4594-4601(1984)

PubMed=2144611; DOI=10.1128/MCB.10.10.5502
Cheng J., Haas M.
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

PubMed=1727382
Cheng J., Yee J.-K., Yeargin J., Friedmann T., Haas M.
Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.
Cancer Res. 52:222-226(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-396
Cell line databases/resources CCLE; BE13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01245
Cosmic-CLP; 906763
DepMap; ACH-002216
LINCS_LDP; LCL-1044
Ontologies CLO; CLO_0001921
Biological sample resources BioSample; SAMN03151896
Chemistry resources ChEMBL-Cells; CHEMBL3308184
ChEMBL-Targets; CHEMBL2366303
GDSC; 906763
PharmacoDB; BE13_84_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669613
Other Wikidata; Q54795852
Polymorphism and mutation databases Cosmic; 906763
Cosmic; 1115589
Cosmic; 1151773
Cosmic; 1330495
Cosmic; 1760518
Cosmic; 2165705
Cosmic; 2602909
IARC_TP53; 21650
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number29