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Cellosaurus BL-70 (CVCL_1088)

Cell line name BL-70
Synonyms BL70; BL 70; IARC/BL70; IARC/BL 70; IARC-BL70; IARC BL70; IARC BL 70
Accession CVCL_1088
Resource Identification Initiative To cite this cell line use: BL-70 (RRID:CVCL_1088)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: International Agency of Research on Cancer (IARC); Lyon; France.
Characteristics: EBV-negative.
Doubling time: ~44 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*32:01,26:01
HLA-BB*49:01,51:01
HLA-CC*14:02,07:01
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:02,06:02
HLA-DRDRB1*13:01,15:01
Disease Burkitt lymphoma (NCIt: C2912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C154 ! BL-63
CVCL_VQ34 ! BL-68
CVCL_M560 ! BL-69
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11
D13S3178,11
D16S53910,11
D5S81811,12
D7S8208,10
TH017,9.3
TPOX8,11
vWA15,17
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=3934070
Lenoir G.M., Vuillaume M., Bonnardel C.
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
IARC Sci. Publ. 60:309-318(1985)

PubMed=2825176; DOI=10.1073/pnas.84.22.8060
Calender A., Billaud M., Aubry J.-P., Banchereau J., Vuillaume M., Lenoir G.M.
Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.
Proc. Natl. Acad. Sci. U.S.A. 84:8060-8064(1987)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22885699; DOI=10.1038/nature11378
Schmitz R., Young R.M., Ceribelli M., Jhavar S., Xiao W., Zhang M., Wright G., Shaffer A.L., Hodson D.J., Buras E., Liu X., Powell J., Yang Y., Xu W., Zhao H., Kohlhammer H., Rosenwald A., Kluin P., Muller-Hermelink H.K., Ott G., Gascoyne R.D., Connors J.M., Rimsza L.M., Campo E., Jaffe E.S., Delabie J., Smeland E.B., Ogwang M.D., Reynolds S.J., Fisher R.I., Braziel R.M., Tubbs R.R., Cook J.R., Weisenburger D.D., Chan W.C., Pittaluga S., Wilson W., Waldmann T.A., Rowe M., Mbulaiteye S.M., Rickinson A.B., Staudt L.M.
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Nature 490:116-120(2012)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections DSMZ; ACC-233
Cell line databases/resources CLDB; cl460
CCLE; BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 910707
GDSC; 910707
LINCS_LDP; LCL-2016
Ontologies BTO; BTO:0003855
CLO; CLO_0001988
Biological sample resources BioSample; SAMN03473383
Chemistry resources ChEMBL-Cells; CHEMBL3308185
ChEMBL-Targets; CHEMBL2366317
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM886890
GEO; GSM887955
Other Wikidata; Q54797245
Polymorphism and mutation databases Cosmic; 910707