Home  |  Contact

Cellosaurus BONNA-12 (CVCL_1090)

[Text version]

Cell line name BONNA-12
Synonyms Bonna-12; BONNA12; Bonna12
Accession CVCL_1090
Resource Identification Initiative To cite this cell line use: BONNA-12 (RRID:CVCL_1090)
Comments Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Characteristics: Has lost chromosome Y.
Doubling time: ~50-60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Spleen.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.35
Native American0
East Asian, North1.04
East Asian, South0
South Asian0
European, North71.7
European, South26.91
Disease Hairy cell leukemia (NCIt: C7402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D5S8189,14
D7S8208,10
D13S31711,14
D16S53912 (Cosmic-CLP)
11,12 (DSMZ)
TH019.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=27463354; DOI=10.3109/10428199109067637
Wientjens G.-J.H.M., Jansen J.H., Wessels H.W., Kibbelaar R.E., Beverstock G.C., Brederoo P., Kluin-Nelemans H.C.
Characterization of a new human B cell line (Bonna-12) with trisomy 9 and trisomy 12 chromosomal abnormality.
Leuk. Lymphoma 5:415-422(1991)

PubMed=1313127
Kluin-Nelemans H.C., Wientjens G.-J.H.M., Jansen J.H.
Establishment of a new human B-cell line (BONNA-12) with trisomy 9 and trisomy 12 chromosomal abnormality.
Leukemia 6:158-158(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F., Martelli M.P., Tabarrini A., Drexler H.G., Falini B.
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-150
Cell line databases/resources CLDB; cl473
CCLE; BONNA12_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00984
Cosmic-CLP; 906695
DepMap; ACH-001452
Ontologies CLO; CLO_0002014
Biological sample resources BioSample; SAMN03473418
Gene expression databases ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1669627
Other Wikidata; Q54797948
Polymorphism and mutation databases Cosmic; 906695
Cosmic; 2690006
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number18