Cellosaurus BONNA-12 (CVCL_1090)

Cell line name BONNA-12
Synonyms Bonna-12
Accession CVCL_1090
Resource Identification Initiative To cite this cell line use: BONNA-12 (RRID:CVCL_1090)
Comments Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Characteristics: Has lost chromosome Y.
Doubling time: ~50-60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Hairy cell leukemia (NCIt: C7402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

D16S53912 (Cosmic-CLP)
11,12 (DSMZ)

PubMed=27463354; DOI=10.3109/10428199109067637
Wientjens G.-J.H.M., Jansen J.H., Wessels H.W., Kibbelaar R.E., Beverstock G.C., Brederoo P., Kluin-Nelemans H.C.
Characterization of a new human B cell line (Bonna-12) with trisomy 9 and trisomy 12 chromosomal abnormality.
Leuk. Lymphoma 5:415-422(1991)

Kluin-Nelemans J.C., Wientjens G.-J.H.M., Jansen J.H.
Establishment of a new human B-cell line (BONNA-12) with trisomy 9 and trisomy 12 chromosomal abnormality.
Leukemia 6:158-158(1992)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F., Martelli M.P., Tabarrini A., Drexler H.G., Falini B.
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections DSMZ; ACC-150
Cell line databases/resources CLDB; cl473
Cosmic-CLP; 906695
Ontologies CLO; CLO_0002014
Biological sample resources BioSample; SAMN03473418
Gene expression databases GEO; GSM1669627
Polymorphism and mutation databases Cosmic; 906695