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Cellosaurus BPH-1 (CVCL_1091)

Cell line name BPH-1
Synonyms BPH1; Benign Prostatic Hyperplasia-1
Accession CVCL_1091
Resource Identification Initiative To cite this cell line use: BPH-1 (RRID:CVCL_1091)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~50 hours (DSMZ=ACC-143).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.5
East Asian, South0.02
South Asian2.82
European, North66.48
European, South29.17
Disease Benign prostatic hyperplasia (NCIt: C2897)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4751 (BPH-1 TETD-A)CVCL_4752 (BPH-1 TETD-B)CVCL_4753 (BPH-1-CAFTD-01)
CVCL_4755 (BPH-1-CAFTD-03)CVCL_4757 (BPH-1-CAFTD-05)CVCL_4759 (BPH-1-CAFTD-07)
Sex of cell Male
Age at sampling 68Y
Category Transformed cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ; Millipore; PubMed=11304728

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133817
D3S135816
D5S81811,12
D7S82010,11
D8S117910,15
D13S31711,12
D16S5399
D18S5110,16
D19S43312,15
D21S1128,32.2
FGA21,24 (DepMap; DSMZ; PubMed=11304728)
24 (Millipore)
Penta D9,14
Penta E7,10
TH016,7
TPOX8,12
vWA17

Run an STR similarity search on this cell line
Web pages https://web.archive.org/web/20150602153427/http://capcelllines.ca:80/details.asp?id=132
Publications

PubMed=7535634; DOI=10.1007/BF02631333
Hayward S.W., Dahiya R., Cunha G.R., Bartek J., Deshpande N., Narayan P.
Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1.
In Vitro Cell. Dev. Biol. Anim. 31:14-24(1995)

PubMed=11304728; DOI=10.1002/pros.1045
van Bokhoven A., Varella-Garcia M., Korch C.T., Hessels D., Miller G.J.
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=11719443
Phillips J.L., Hayward S.W., Wang Y.-Z., Vasselli J., Pavlovich C.P., Padilla-Nash H.M., Pezullo J.R., Ghadimi B.M., Grossfeld G.D., Rivera A., Linehan W.M., Cunha G.R., Ried T.
The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis.
Cancer Res. 61:8143-8149(2001)

CLPUB00698
van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21248069; DOI=10.1158/0008-5472.CAN-10-1998
Li Y.-M., Alsagabi M., Fan D.-H., Bova G.S., Tewfik A.H., Dehm S.M.
Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression.
Cancer Res. 71:2108-2117(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-143
ICLC; HTL11006
Millipore; SCC256
Cell line databases/resources CLO; CLO_0002022
CLDB; cl7219
cancercelllines; CVCL_1091
Cell_Model_Passport; SIDM00964
Cosmic-CLP; 924105
DepMap; ACH-001453
DSMZCellDive; ACC-143
IGRhCellID; BPH1
LINCS_HMS; 50005
LINCS_LDP; LCL-2095
SKY/M-FISH/CGH; 1510
Anatomy/cell type resources BTO; BTO:0001323
Biological sample resources BioSample; SAMN03473417
Chemistry resources ChEMBL-Cells; CHEMBL3308186
ChEMBL-Targets; CHEMBL2366131
GDSC; 924105
PharmacoDB; BPH1_107_2019
PubChem_Cell_line; CVCL_1091
Encyclopedic resources Wikidata; Q54798059
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827571
GEO; GSM1374405
GEO; GSM1669628
Polymorphism and mutation databases Cosmic; 924105
Cosmic; 1995347
IARC_TP53; 27687
Progenetix; CVCL_1091
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number34