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Cellosaurus BPH-1 (CVCL_1091)

[Text version]

Cell line name BPH-1
Synonyms BPH1; Benign Prostatic Hyperplasia-1
Accession CVCL_1091
Resource Identification Initiative To cite this cell line use: BPH-1 (RRID:CVCL_1091)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Prostate.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.5
East Asian, South0.02
South Asian2.82
European, North66.48
European, South29.17
Disease Benign prostatic hyperplasia (NCIt: C2897)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4751 (BPH-1 TETD-A)CVCL_4752 (BPH-1 TETD-B)CVCL_4753 (BPH-1-CAFTD-01)
CVCL_4755 (BPH-1-CAFTD-03)CVCL_4757 (BPH-1-CAFTD-05)CVCL_4759 (BPH-1-CAFTD-07)
Sex of cell Male
Age at sampling 68Y
Category Transformed cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,12
D7S82010,11
D13S31711,12
D16S5399
TH016,7
TPOX8,12
vWA17

Run an STR similarity search on this cell line
Web pages https://web.archive.org/web/20150602153427/http://capcelllines.ca:80/details.asp?id=132
Publications

PubMed=7535634; DOI=10.1007/BF02631333
Hayward S.W., Dahiya R., Cunha G.R., Bartek J., Deshpande N., Narayan P.
Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1.
In Vitro Cell. Dev. Biol. Anim. 31:14-24(1995)

PubMed=11719443
Phillips J.L., Hayward S.W., Wang Y., Vasselli J., Pavlovich C.P., Padilla-Nash H.M., Pezullo J.R., Ghadimi B.M., Grossfeld G.D., Rivera A., Linehan W.M., Cunha G.R., Ried T.
The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis.
Cancer Res. 61:8143-8149(2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21248069; DOI=10.1158/0008-5472.CAN-10-1998
Li Y., Alsagabi M., Fan D., Bova G.S., Tewfik A.H., Dehm S.M.
Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression.
Cancer Res. 71:2108-2117(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-143
ICLC; HTL11006
Cell line databases/resources CLDB; cl7219
CCLE; BPH1_PROSTATE
Cell_Model_Passport; SIDM00964
Cosmic-CLP; 924105
DepMap; ACH-001453
IGRhCellID; BPH1
LINCS_HMS; 50005
LINCS_LDP; LCL-2095
SKY/M-FISH/CGH; 1510
Ontologies BTO; BTO:0001323
CLO; CLO_0002022
Biological sample resources BioSample; SAMN03473417
Chemistry resources ChEMBL-Cells; CHEMBL3308186
ChEMBL-Targets; CHEMBL2366131
GDSC; 924105
PharmacoDB; BPH1_107_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827571
GEO; GSM1374405
GEO; GSM1669628
Other Wikidata; Q54798059
Polymorphism and mutation databases Cosmic; 924105
Cosmic; 1995347
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number25