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Cellosaurus C-33 A (CVCL_1094)

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Cell line name C-33 A
Synonyms C33A; C33a; C33-A; C-33-A; C-33A; C33
Accession CVCL_1094
Resource Identification Initiative To cite this cell line use: C-33 A (RRID:CVCL_1094)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Doubling time: 1.36 days (PubMed=29156801).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Arg273Cys (c.817C>T) (ClinVar=VCV000043594) (PubMed=1648218).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.33
East Asian, North0.48
East Asian, South0.19
South Asian0.82
European, North66.58
European, South31.19
Disease Cervical squamous cell carcinoma, not otherwise specified (NCIt: C4028)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4J71 (HOE6V)CVCL_X008 (SK-OV-4)CVCL_A457 (SK-OV-6)
Originate from same individual CVCL_1E27 ! C-33 B
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CCRID; Cosmic-CLP; DepMap; PubMed=25877200

D18S5115,17,18 (DepMap)
15,18 (PubMed=25877200)
Penta D10
Penta E6,8

Run an STR similarity search on this cell line
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-23.html

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Auersperg N.
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1648218; DOI=10.1073/pnas.88.13.5523
Scheffner M., Munger K., Byrne J.C., Howley P.M.
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 88:5523-5527(1991)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24134916; DOI=10.1186/1755-8166-6-44
McCormack A., Fan J.L., Duesberg M., Bloomfield M., Fiala C., Duesberg P.
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44-44(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections AddexBio; C0008003/382
BCRC; 60554
BCRJ; 0348
ICLC; HTL02004
Cell line databases/resources CLDB; cl7126
CCRID; 3111C0001CCC000172
CCRID; 3111C0002000000091
CCRID; 3131C0001000700176
CCRID; 3142C0001000000132
Cell_Model_Passport; SIDM00889
Cosmic-CLP; 687505
DepMap; ACH-001333
IGRhCellID; C33A
Ontologies BTO; BTO:0001968
CLO; CLO_0002115
EFO; EFO_0002120
Biological sample resources BioSample; SAMN03473073
Chemistry resources ChEMBL-Cells; CHEMBL3308230
ChEMBL-Targets; CHEMBL614370
ChEMBL-Targets; CHEMBL2366313
GDSC; 687505
PharmacoDB; C33A_150_2019
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM253296
GEO; GSM675730
GEO; GSM685441
GEO; GSM1669637
Other Wikidata; Q54799738
Polymorphism and mutation databases Cosmic; 687505
Cosmic; 760217
Cosmic; 809226
Cosmic; 846180
Cosmic; 877470
Cosmic; 925355
Cosmic; 928905
Cosmic; 1071910
Cosmic; 1131520
Cosmic; 1176610
Cosmic; 1193030
Cosmic; 1201776
Cosmic; 1324210
Cosmic; 1995353
Cosmic; 2301537
Cosmic; 2602729
Cosmic; 2660188
Cosmic; 2791020
Cosmic; 2816218
IARC_TP53; 324
Progenetix; CVCL_1094
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number36