ID   C-33 A
AC   CVCL_1094
SY   C33A; C33a; C33-A; C-33-A; C-33A; C33
DR   BTO; BTO:0001968
DR   CLO; CLO_0002115
DR   EFO; EFO_0002120
DR   CLDB; cl7126
DR   AddexBio; C0008003/382
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-31
DR   ATCC; CRM-HTB-31
DR   BCRC; 60554
DR   BCRJ; 0348
DR   BioSample; SAMN03473073
DR   cancercelllines; CVCL_1094
DR   CCRID; 1101HUM-PUMC000172
DR   CCRID; 1102HUM-NIFDC00091
DR   CCRID; 3101HUMTCHu176
DR   CCRID; 4201HUM-CCTCC00144
DR   CCTCC; GDC0144
DR   Cell_Model_Passport; SIDM00889
DR   ChEMBL-Cells; CHEMBL3308230
DR   ChEMBL-Targets; CHEMBL614370
DR   ChEMBL-Targets; CHEMBL2366313
DR   CLS; 305072
DR   Cosmic; 687505
DR   Cosmic; 760217
DR   Cosmic; 809226
DR   Cosmic; 846180
DR   Cosmic; 877470
DR   Cosmic; 925355
DR   Cosmic; 928905
DR   Cosmic; 1071910
DR   Cosmic; 1131520
DR   Cosmic; 1176610
DR   Cosmic; 1193030
DR   Cosmic; 1201776
DR   Cosmic; 1324210
DR   Cosmic; 1995353
DR   Cosmic; 2301537
DR   Cosmic; 2602729
DR   Cosmic; 2660188
DR   Cosmic; 2791020
DR   Cosmic; 2816218
DR   Cosmic-CLP; 687505
DR   DepMap; ACH-001333
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 687505
DR   GEO; GSM253296
DR   GEO; GSM675730
DR   GEO; GSM685441
DR   GEO; GSM1669637
DR   IARC_TP53; 324
DR   ICLC; HTL02004
DR   IGRhCellID; C33A
DR   LINCS_LDP; LCL-1300
DR   PharmacoDB; C33A_150_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1094
DR   PubChem_Cell_line; CVCL_1094
DR   Wikidata; Q54799738
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=1648218;
RX   PubMed=2990217;
RX   PubMed=3518877;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=14114965;
RX   PubMed=15531914;
RX   PubMed=20215515;
RX   PubMed=24134916;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28261610;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35692560;
RX   PubMed=35839778;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-23.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
CC   Population: Caucasian.
CC   Doubling time: 1.36 days (PubMed=29156801).
CC   HLA typing: A*02:01,03:01; B*07:02,44:02; C*05:01,07:02 (PubMed=26589293).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=1648218).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Secretome proteome analysis by 2D-DE/MS.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.41%; Native American=0.33%; East Asian, North=0.48%; East Asian, South=0.19%; South Asian=0.82%; European, North=66.58%; European, South=31.19% (PubMed=30894373).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): AddexBio; ATCC; CCRID; Cosmic-CLP; DepMap; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 13
ST   D16S539: 13,14
ST   D18S51: 15,17,18 (DepMap)
ST   D18S51: 15,18 (PubMed=25877200)
ST   D19S433: 11,13,14
ST   D21S11: 29,30,31
ST   D2S1338: 23,25
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 10,14
ST   FGA: 21,26
ST   Penta D: 10
ST   Penta E: 6,8
ST   TH01: 7,8
ST   TPOX: 9
ST   vWA: 18,20
DI   NCIt; C180841; Human papillomavirus-independent cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1E27 ! C-33 B
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 46
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=1648218; DOI=10.1073/pnas.88.13.5523;
RA   Scheffner M., Munger K., Byrne J.C., Howley P.M.;
RT   "The state of the p53 and retinoblastoma genes in human cervical
RT   carcinoma cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5523-5527(1991).
//
RX   PubMed=2990217;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=14114965; DOI=10.1093/jnci/32.1.135;
RA   Auersperg N.;
RT   "Long-term cultivation of hypodiploid human tumor cells.";
RL   J. Natl. Cancer Inst. 32:135-163(1964).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44;
RA   McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C.,
RA   Duesberg P.H.;
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28261610; DOI=10.1155/2017/4180703;
RA   Kontostathi G., Zoidakis J., Makridakis M., Lygirou V., Mermelekas G.,
RA   Papadopoulos T., Vougas K., Vlamis-Gardikas A., Drakakis P.,
RA   Loutradis D., Vlahou A., Anagnou N.P., Pappa K.I.;
RT   "Cervical cancer cell line secretome highlights the roles of
RT   transforming growth factor-beta-induced protein ig-h3,
RT   peroxiredoxin-2, and NRF2 on cervical carcinogenesis.";
RL   Biomed Res. Int. 2017:4180703.1-4180703.15(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35692560; DOI=10.1080/23723556.2022.2078628;
RA   de Lourdes Zuniga-Martinez M., Lopez-Mendoza C.M., Tenorio-Salazar J.,
RA   Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.;
RT   "Establishment, authenticity, and characterization of cervical cancer
RT   cell lines.";
RL   Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//