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Cellosaurus C-4-II (CVCL_1095)

Cell line name C-4-II
Synonyms C-4 II; C4 II; C4II
Accession CVCL_1095
Resource Identification Initiative To cite this cell line use: C-4-II (RRID:CVCL_1095)
Comments Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Characteristics: Contains a complete HPV18 genome.
Doubling time: 2.4 days (PubMed=29156801).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2253 ! C-4-I
Sex of cell Female
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): ATCC; ECACC; PubMed=29156801


PubMed=13863218; DOI=10.1093/jnci/28.3.605
Auersperg N., Hawryluk A.P.
Chromosome observations on three epithelial-cell cultures derived from carcinomas of the human cervix.
J. Natl. Cancer Inst. 28:605-627(1962)

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Auersperg N.
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=5796380; DOI=10.1093/jnci/43.1.151
Auersperg N.
Histogenetic behavior of tumors. I. Morphologic variation in vitro and in vivo of two related human carcinoma cell lines.
J. Natl. Cancer Inst. 43:151-173(1969)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cell line collections ATCC; CRL-1595
ATCC; CRL-7914 - Discontinued
ECACC; 88102701
Cell line databases/resources CLDB; cl571
Ontologies CLO; CLO_0002126
EFO; EFO_0002123
Biological sample resources BioSample; SAMN03471403
Chemistry resources ChEMBL-Cells; CHEMBL3308712
ChEMBL-Targets; CHEMBL1075400
Gene expression databases GEO; GSM675732
GEO; GSM685437
Other Wikidata; Q54799745
Polymorphism and mutation databases Cosmic; 760218
Cosmic; 809230
Cosmic; 910553