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Cellosaurus C8166 (CVCL_1099)

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Cell line name C8166
Synonyms C8166-CD4
Accession CVCL_1099
Resource Identification Initiative To cite this cell line use: C8166 (RRID:CVCL_1099)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.3
Native American0.05
East Asian, North1.72
East Asian, South0
South Asian0
European, North64.43
European, South33.5
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0195 (C8166/45)CVCL_1H07 (M8166)
Sex of cell Male
Category Transformed cell line
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0013&theme=default
http://www.cellresource.cn/fdetail.aspx?id=399
Publications

PubMed=12920029; DOI=10.1182/blood-2003-04-1043
Chung H.-K., Young H.A., Goon P.K.C., Heidecker G., Princler G.L., Shimozato O., Taylor G.P., Bangham C.R.M., Derse D.
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.
Blood 102:4130-4136(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ECACC; 88051601
KCB; KCB 94019YJ
Cell line databases/resources CLDB; cl589
CCLE; C8166_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3111C0002000000027
Cell_Model_Passport; SIDM00072
DepMap; ACH-000206
LINCS_LDP; LCL-1011
Ontologies CLO; CLO_0002149
Biological sample resources BioSample; SAMN10989599
Chemistry resources ChEMBL-Cells; CHEMBL3307638
ChEMBL-Targets; CHEMBL614533
PharmacoDB; C8166_157_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827337
GEO; GSM1669640
Other Wikidata; Q54808257
Polymorphism and mutation databases Cosmic; 906829
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number24