ID   Ca Ski
AC   CVCL_1100
SY   Ca-Ski; CaSki; Caski; CASKI
DR   BTO; BTO:0003109
DR   CLO; CLO_0002165
DR   CLO; CLO_0002201
DR   CLO; CLO_0050930
DR   EFO; EFO_0006549
DR   CLDB; cl603
DR   CLDB; cl604
DR   CLDB; cl605
DR   CLDB; cl4940
DR   AddexBio; C0008004/375
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1550
DR   ATCC; CRM-CRL-1550
DR   ATCC; CRL-7915
DR   BCRC; 60251
DR   BioSample; SAMN01821540
DR   BioSample; SAMN01821672
DR   BioSample; SAMN01821725
DR   BioSample; SAMN03473214
DR   CCLE; CASKI_CERVIX
DR   CCRID; 3111C0001CCC000101
DR   CCRID; 3111C0002000000093
DR   CCRID; 3131C0001000700137
DR   CCRID; 3142C0001000000117
DR   CCTCC; GDC0111
DR   Cell_Model_Passport; SIDM00923
DR   ChEMBL-Cells; CHEMBL3308097
DR   ChEMBL-Targets; CHEMBL1075403
DR   CLS; 300145/p498_CaSki
DR   Cosmic; 687507
DR   Cosmic; 760221
DR   Cosmic; 809232
DR   Cosmic; 846182
DR   Cosmic; 877469
DR   Cosmic; 906824
DR   Cosmic; 925357
DR   Cosmic; 928904
DR   Cosmic; 1019307
DR   Cosmic; 1131519
DR   Cosmic; 1193033
DR   Cosmic; 1201775
DR   Cosmic; 1324211
DR   Cosmic; 1995364
DR   Cosmic; 2060797
DR   Cosmic; 2301538
DR   Cosmic; 2646655
DR   Cosmic; 2660195
DR   Cosmic; 2668297
DR   Cosmic-CLP; 906824
DR   DepMap; ACH-001336
DR   ECACC; 87020501
DR   GDSC; 906824
DR   GEO; GSM29720
DR   GEO; GSM113861
DR   GEO; GSM226732
DR   GEO; GSM226867
DR   GEO; GSM253297
DR   GEO; GSM675733
DR   GEO; GSM685445
DR   GEO; GSM723053
DR   GEO; GSM723054
DR   GEO; GSM827309
DR   GEO; GSM1669667
DR   IARC_TP53; 21261
DR   IBRC; C10345
DR   ICLC; HTL98018
DR   IGRhCellID; CaSki%20GEO
DR   IZSLER; BS TCL 201
DR   JCRB; IFO50007
DR   KCB; KCB 2013034YJ
DR   KCLB; 21550
DR   LINCS_HMS; 50006
DR   LINCS_LDP; LCL-1541
DR   Lonza; 1669
DR   PharmacoDB; CaSki_158_2019
DR   RCB; RCB1947
DR   TKG; TKG 0366
DR   Wikidata; Q54808287
RX   CelloPub=CLPUB00481;
RX   PubMed=867042;
RX   PubMed=2990217;
RX   PubMed=3029430;
RX   PubMed=3371749;
RX   PubMed=7751322;
RX   PubMed=9887230;
RX   PubMed=15531914;
RX   PubMed=17311676;
RX   PubMed=17611311;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=21439369;
RX   PubMed=24134916;
RX   PubMed=24201445;
RX   PubMed=25485619;
RX   PubMed=27397505;
RX   PubMed=29156801;
RX   PubMed=30894373;
WW   http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-21.html
WW   http://www.cellresource.cn/fdetail.aspx?id=101
WW   http://www.cellresource.cn/fdetail.aspx?id=705
WW   http://www.cellresource.cn/fdetail.aspx?id=885
WW   http://www.cellresource.cn/fdetail.aspx?id=2118
CC   Group: Space-flown cell line (cellonaut).
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Characteristics: Contains from 100 to 800 copies of the HPV16 genome; some complete and others truncated.
CC   Doubling time: 3.2 days (PubMed=29156801).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Has no TP53 mutation (PubMed=9887230).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=1.02%; Native American=0%; East Asian, North=1.86%; East Asian, South=0%; South Asian=0%; European, North=68.36%; European, South=28.76% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7915; true.
CC   Derived from metastatic site: Small intestine.
ST   Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=25877200; PubMed=29156801; RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8,12
ST   D16S539: 11,12
ST   D18S51: 17
ST   D19S433: 15,16
ST   D21S11: 30
ST   D2S1338: 21
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 8,11
ST   D8S1179: 15
ST   FGA: 21
ST   Penta D: 10
ST   Penta E: 5
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   40Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 12-03-20; Version: 30
//
RX   CelloPub=CLPUB00481;
RA   Kuno H., Yoshida T.;
RT   "Detection of human papillomavirus types 16, 18, and 33 in cell lines
RT   derived from human genital organs by polymerase chain reaction.";
RL   Res. Commun. Inst. Ferment. Osaka 18:6-12(1997).
//
RX   PubMed=867042; DOI=10.1126/science.867042;
RA   Pattillo R.A., Hussa R.O., Story M.T., Ruckert A.C.F., Shalaby M.R.,
RA   Mattingly R.F.;
RT   "Tumor antigen and human chorionic gonadotropin in CaSki cells: a new
RT   epidermoid cervical cancer cell line.";
RL   Science 196:1456-1458(1977).
//
RX   PubMed=2990217;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3029430;
RA   Baker C.C., Phelps W.C., Lindgren V., Braun M.J., Gonda M.A.,
RA   Howley P.M.;
RT   "Structural and transcriptional analysis of human papillomavirus type
RT   16 sequences in cervical carcinoma cell lines.";
RL   J. Virol. 61:962-971(1987).
//
RX   PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7;
RA   Grenman S.E., Shapira A., Carey T.E.;
RT   "In vitro response of cervical cancer cell lines CaSki, HeLa, and
RT   ME-180 to the antiestrogen tamoxifen.";
RL   Gynecol. Oncol. 30:228-238(1988).
//
RX   PubMed=7751322; DOI=10.1007/BF01366967;
RA   Rantanen V., Grenman S.E., Kulmala J., Grenman R.;
RT   "The intrinsic radiosensitivity and sublethal damage repair capacity
RT   of five cervical carcinoma cell lines tested with the 96-well-plate
RT   assay.";
RL   J. Cancer Res. Clin. Oncol. 121:230-234(1995).
//
RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen V., Grenman S.E., Kurvinen K., Hietanen S., Raitanen M.,
RA   Syrjanen S.;
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=17311676; DOI=10.1186/1471-2164-8-53;
RA   Kloth J.N., Oosting J., van Wezel T., Szuhai K., Knijnenburg J.,
RA   Gorter A., Kenter G.G., Fleuren G.J., Jordanova E.S.;
RT   "Combined array-comparative genomic hybridization and
RT   single-nucleotide polymorphism-loss of heterozygosity analysis reveals
RT   complex genetic alterations in cervical cancer.";
RL   BMC Genomics 8:53-53(2007).
//
RX   PubMed=17611311;
RA   Yang C., Li G.-C., Li Y.-H., Hu J.-Y., Xiao Y., Zhang Z.-J.;
RT   "Biological properties of Caski cell lines induced by exposing to the
RT   space environment.";
RL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:380-386(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003;
RA   Schmitt M., Pawlita M.;
RT   "The HPV transcriptome in HPV16 positive cell lines.";
RL   Mol. Cell. Probes 25:108-113(2011).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44;
RA   McCormack A., Fan J.L., Duesberg M., Bloomfield M., Fiala C.,
RA   Duesberg P.;
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44-44(2013).
//
RX   PubMed=24201445; DOI=10.1101/gr.164806.113;
RA   Akagi K., Li J., Broutian T.R., Padilla-Nash H.M., Xiao W., Jiang B.,
RA   Rocco J.W., Teknos T.N., Kumar B., Wangsa D., He D., Ried T.,
RA   Symer D.E., Gillison M.L.;
RT   "Genome-wide analysis of HPV integration in human cancers reveals
RT   recurrent, focal genomic instability.";
RL   Genome Res. 24:185-199(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y.,
RA   Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J.,
RA   Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//