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Cellosaurus Ca9-22 (CVCL_1102)

[Text version]

Cell line name Ca9-22
Synonyms CA9-22; Ca 9-22; CA922; Ca922
Accession CVCL_1102
Resource Identification Initiative To cite this cell line use: Ca9-22 (RRID:CVCL_1102)
Comments Problematic cell line: Partially contaminated. Some stocks of Ca9-22 are contaminated with MSK-922 (PubMed=21868764).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00437.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Arg248Trp (c.742C>T) (PubMed=1570156; PubMed=10741724).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*02:07,24:02
HLA-BB*35,46:01
HLA-CC*01:02,14:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.96
Native American0
East Asian, North79.73
East Asian, South18.82
South Asian0
European, North0
European, South0.49
Disease Gingival squamous cell carcinoma (NCIt: C129857)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HM42 (Ca9-22PF)CVCL_HM41 (Ca9-22SF)CVCL_2789 (KOSC-3)
Sex of cell Male
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO12
D5S81812
D7S82011,13
D13S31711
D16S5399,10
TH016
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=4549822; DOI=10.5794/jjoms.20.100
Horikoshi M., Kimura Y., Nagura H., Ono T., Ito H.
A new human cell line derived from human carcinoma of the gingiva. I Its establishment and morphological studies.
Nihon Koku Geka Gakkai Zasshi 20:100-106(1974)

DOI=10.5794/jjoms.23.619
Horikoshi M., Katsumura A., Fujibayashi T., Soda T., Itoh H.
Lymphocyte mediated cytotoxicity to oral squamous cell carcinoma cell line (Ca 9-22).
Nihon Koku Geka Gakkai Zasshi 23:619-625(1977)

PubMed=275414; DOI=10.5357/koubyou.45.20
Kimura Y.
Studies on lactate dehydrogenase isoenzymes in a cell line (Ca 9-22) derived from carcinoma of the gingiva.
Kokubyo Gakkai Zasshi 45:20-35(1978)

PubMed=2228902; DOI=10.1007/BF02624609
Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
In Vitro Cell. Dev. Biol. 26:849-856(1990)

PubMed=1570156
Sakai E., Tsuchida N.
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Oncogene 7:927-933(1992)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M., Itoh K.
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=9247707; DOI=10.1080/15216549700202901
Hatakeyama S., Gao Y.-H., Ohara-Nemoto Y., Kataoka H., Satoh M.
Expression of bone morphogenetic proteins of human neoplastic epithelial cells.
Biochem. Mol. Biol. Int. 42:497-505(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=10741724
Eura M., Chikamatsu K., Katsura F., Obata A., Sobao Y., Takiguchi M., Song Y., Appella E., Whiteside T.L., DeLeo A.B.
A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck.
Clin. Cancer Res. 6:979-986(2000)

PubMed=12738951; DOI=10.1067/moe.2003.36
Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003)

PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x
Kozaki K.-I., Imoto I., Pimkhaokham A., Hasegawa S., Tsuda H., Omura K., Inazawa J.
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Cancer Sci. 97:1351-1358(2006)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-I., Nose M., Miki T., Hamakawa H.
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=18097548; DOI=10.3892/ijo.32.1.101
Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Int. J. Oncol. 32:101-111(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0625
RCB; RCB1976
TKG; TKG 0485
Cell line databases/resources CCLE; CA922_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00489
CGH-DB; 355-2
Cosmic-CLP; 753538
DepMap; ACH-002043
GDSC; 753538
LINCS_HMS; 50007
LINCS_LDP; LCL-2033
Ontologies BTO; BTO:0005204
CLO; CLO_0051380
Biological sample resources BioSample; SAMN01821673
Chemistry resources ChEMBL-Cells; CHEMBL3308714
ChEMBL-Targets; CHEMBL1075404
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM301576
GEO; GSM827235
GEO; GSM850380
GEO; GSM1669642
Other Wikidata; Q54808305
Polymorphism and mutation databases Cosmic; 753538
Cosmic; 930339
Cosmic; 932155
Cosmic; 1042302
Cosmic; 1046026
Cosmic; 1118791
Cosmic; 1120700
Cosmic; 1123036
Cosmic; 1140783
Cosmic; 1219867
Cosmic; 1317411
Cosmic; 2266786
Cosmic; 2546832
IARC_TP53; 1095
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number26