Cellosaurus CAL-27 (CVCL_1107)

Cell line name CAL-27
Synonyms Cal-27; CAL 27; Cal 27; CAL27; Cal27
Accession CVCL_1107
Resource Identification Initiative To cite this cell line use: CAL-27 (RRID:CVCL_1107)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Doubling time: ~20-40 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: TP53 p.His193Leu (PubMed=25275298).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_GY99 (CAL-27 TPFR); CVCL_EI26 (ER-Cal-27)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=21868764; PubMed=25275298; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S31710,11
D16S53911,12
D18S5113
D21S1128,29
D3S135816
D5S81811,12
D7S82010
D8S117913,15
FGA25
Penta D9,10
Penta E7
TH016,9.3
TPOX8
vWA14,17
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=2440566
Gioanni J., Samson M., Zanghellini E., Mazeau C., Ettore F., Demard F., Chauvel P., Duplay H., Schneider M., Laurent J.-C., Lalanne C.-M.
Characterization of a new surface epitope specific for human epithelial cells defined by a monoclonal antibody and application to tumor diagnosis.
Cancer Res. 47:4417-4424(1987)

PubMed=3181269; DOI=10.1016/0277-5379(88)90335-5
Gioanni J., Fischel J.-L., Lambert J.-C., Demard F., Mazeau C., Zanghellini E., Ettore F., Formento P., Chauvel P., Lalanne C.-M., Courdi A.
Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.
Eur. J. Cancer Clin. Oncol. 24:1445-1455(1988)

PubMed=2145926; DOI=10.1016/0277-5379(90)90186-W
Olivier S., Formento P., Fischel J.-L., Etienne M.-C., Milano G.
Epidermal growth factor receptor expression and suramin cytotoxicity in vitro.
Eur. J. Cancer 26:867-871(1990)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008
Stanam A., Love-Homan L., Joseph T.S., Espinosa-Cotton M., Simons A.L.
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28476783; DOI=10.21873/anticanres.11555
Hagemann J., Jacobi C., Hahn M., Schmid V., Welz C., Schwenk-Zieger S., Stauber R., Baumeister P., Becker S.
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Anticancer Res. 37:2201-2210(2017)

Cross-references
Cell line collections ATCC; CRL-2095
BCRJ; 0326
DSMZ; ACC-446
Cell line databases/resources CCLE; CAL27_UPPER_AERODIGESTIVE_TRACT
CCRID; 3111C0001CCC000338
Cosmic-CLP; 910916
GDSC; 910916
IGRhCellID; CAL27%20GSE9585
LINCS_LDP; LCL-1215
Ontologies BTO; BTO:0000921
CLO; CLO_0002178
CLO; CLO_0002182
EFO; EFO_0006366
Biological sample resources BioSample; SAMN03471886
Chemistry resources ChEMBL-Cells; CHEMBL3308098
ChEMBL-Targets; CHEMBL1075408
Gene expression databases GEO; GSM422868
GEO; GSM886907
GEO; GSM887972
GEO; GSM1374427
GEO; GSM1374428
GEO; GSM1519074
GEO; GSM1519075
GEO; GSM1519076
GEO; GSM1669648
Polymorphism and mutation databases Cosmic; 686972
Cosmic; 910916
Cosmic; 1006469
Cosmic; 1017793
Cosmic; 1041674
Cosmic; 1339913
Cosmic; 1466800
Cosmic; 1530734
Cosmic; 1752762
Cosmic; 2043896
Cosmic; 2131842
Cosmic; 2296292