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Cellosaurus CAL-33 (CVCL_1108)

[Text version]

Cell line name CAL-33
Synonyms Cal-33; CAL 33; CAL33; Centre Antoine Lacassagne-33
Accession CVCL_1108
Resource Identification Initiative To cite this cell line use: CAL-33 (RRID:CVCL_1108)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Doubling time: 78 hours (PubMed=2145926); ~30-40 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Arg175His (c.524G>A) (PubMed=25275298).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.92
Native American0
East Asian, North2.32
East Asian, South0.33
South Asian0
European, North46.86
European, South49.56
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25275298

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135817
D5S81811,12
D7S8208,10
D8S117913
D13S3178,13
D16S53911
D18S5114
D21S1129,30
FGA21,22
Penta D12,13
Penta E7,15
TH019,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2440566
Gioanni J., Samson M., Zanghellini E., Mazeau C., Ettore F., Demard F., Chauvel P., Duplay H., Schneider M., Laurent J.-C., Lalanne C.-M.
Characterization of a new surface epitope specific for human epithelial cells defined by a monoclonal antibody and application to tumor diagnosis.
Cancer Res. 47:4417-4424(1987)

PubMed=3181269; DOI=10.1016/0277-5379(88)90335-5
Gioanni J., Fischel J.-L., Lambert J.-C., Demard F., Mazeau C., Zanghellini E., Ettore F., Formento P., Chauvel P., Lalanne C.-M., Courdi A.
Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.
Eur. J. Cancer Clin. Oncol. 24:1445-1455(1988)

PubMed=2145926; DOI=10.1016/0277-5379(90)90186-W
Olivier S., Formento P., Fischel J.-L., Etienne M.-C., Milano G.
Epidermal growth factor receptor expression and suramin cytotoxicity in vitro.
Eur. J. Cancer 26:867-871(1990)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24710094; DOI=10.3390/genes1030388
Bauer V.L., Hieber L., Schaeffner Q., Weber J., Braselmann H., Huber R., Walch A., Zitzelsberger H.
Establishment and molecular cytogenetic characterization of a cell culture model of head and neck squamous cell carcinoma (HNSCC).
Genes (Basel) 1:388-412(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-447
Cell line databases/resources CCLE; CAL33_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00942
Cosmic-CLP; 753541
DepMap; ACH-000518
GDSC; 753541
LINCS_LDP; LCL-1216
Ontologies BTO; BTO:0000941
CLO; CLO_0002183
Biological sample resources BioSample; SAMN03473547
BioSample; SAMN10988048
Chemistry resources ChEMBL-Cells; CHEMBL3308715
ChEMBL-Targets; CHEMBL1075409
PharmacoDB; CAL33_170_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887974
GEO; GSM1669650
Other Wikidata; Q54808398
Polymorphism and mutation databases Cosmic; 753541
Cosmic; 2296293
IARC_TP53; 21210
LiGeA; CCLE_328
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number26