Cellosaurus CAL-54 (CVCL_1111)

Cell line name CAL-54
Synonyms CAL 54; CAL54
Accession CVCL_1111
Resource Identification Initiative To cite this cell line use: CAL-54 (RRID:CVCL_1111)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 35 +- 2 hours, at 14th passage (PubMed=8868943); ~72 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Renal cell carcinoma (NCIt: C9385)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S31713,14
D16S53913
D18S5113,14
D21S1130.2
D3S135817
D5S81811,13
D7S82010
D8S11799,12
FGA22,23
Penta D10,13
Penta E7,19
TH016,9
TPOX8,9
vWA17,18
Publications

PubMed=8868943
Gioanni J., Zanghellini E., Mazeau C., Amiel J., Poustis-Delpont C., Lagrange J.-L., Duplay H., Caldani C., Courdi A.
CAL 54, a new cell line derived from a human renal carcinoma: characterization and radiosensitivity.
Bull. Cancer 83:553-558(1996)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-365
Cell line databases/resources CCLE; CAL54_KIDNEY
Cosmic-CLP; 910952
GDSC; 910952
IGRhCellID; CAL54
LINCS_LDP; LCL-1757
Ontologies CLO; CLO_0002186
EFO; EFO_0002125
Biological sample resources BioSample; SAMN03473166
Chemistry resources ChEMBL-Cells; CHEMBL3308346
ChEMBL-Targets; CHEMBL1075412
Gene expression databases GEO; GSM886910
GEO; GSM887976
GEO; GSM1669653
Polymorphism and mutation databases Cosmic; 910952