Cellosaurus CAL-62 (CVCL_1112)

Cell line name CAL-62
Synonyms Cal-62; CAL 62; CAL62
Accession CVCL_1112
Resource Identification Initiative To cite this cell line use: CAL-62 (RRID:CVCL_1112)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~24 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Thyroid gland undifferentiated (anaplastic) carcinoma (NCIt: C3878)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=18713817

Markers:
AmelogeninX
CSF1PO9,12
D13S31712
D16S53912,13
D18S5116
D21S1132.2
D3S135816
D5S8189,12
D7S82010
D8S117913
FGA19
TH017,9
TPOX8,9
vWA16
Publications

PubMed=1369551
Gioanni J., Zanghellini E., Mazeau C., Zhang D., Courdi A., Farges M.-F., Lambert J.-C., Duplay H., Schneider M.
Characterization of a human cell line from an anaplastic carcinoma of the thyroid gland.
Bull. Cancer 78:1053-1062(1991)

PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A., Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-448
Cell line databases/resources CCLE; CAL62_THYROID
Cosmic-CLP; 906828
GDSC; 906828
IGRhCellID; CAL62
LINCS_LDP; LCL-1683
Ontologies BTO; BTO:0002146
CLO; CLO_0002187
EFO; EFO_0002126
Biological sample resources BioSample; SAMN03473548
Chemistry resources ChEMBL-Cells; CHEMBL3308099
ChEMBL-Targets; CHEMBL1075413
Gene expression databases GEO; GSM886911
GEO; GSM887977
GEO; GSM1669654
Polymorphism and mutation databases Cosmic; 891257
Cosmic; 906828
Cosmic; 1152118
Cosmic; 1162838
Cosmic; 1239974
Cosmic; 2054116
Cosmic; 2613252