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Cellosaurus CGTH-W-1 (CVCL_1120)

Cell line name CGTH-W-1
Synonyms CGTH-W1; CGTH W-1; CGTHW1
Accession CVCL_1120
Resource Identification Initiative To cite this cell line use: CGTH-W-1 (RRID:CVCL_1120)
Comments Problematic cell line: Contaminated. Shown to be a SW579 derivative (PubMed=25877200, DSMZ). Originally thought to originate from a thyroid gland follicular carcinoma metastasizing to the sternum of a 70 year old Chinese female patient.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00536.
Doubling time: ~20-25 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for TERT c.228C>T (-124C>T); in promoter (PubMed=23833040).
Disease Thyroid gland squamous cell carcinoma (NCIt: C46008)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3603 (SW579)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

D5S8189,11 (DSMZ)
11 (Cosmic-CLP; PubMed=25877200)
Penta D9
Penta E11
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx

PubMed=8826082; DOI=10.1007/BF02634562
Lin J.-D., Ho Y.-S., Chang H.-Y., Weng H.-F.
The role of insulin-like growth factor-1 (IGF-1) in follicular thyroid cancer cell line CGTH W-1.
In Vitro Cell. Dev. Biol. Anim. 31:817-821(1995)

PubMed=8888804; DOI=10.1002/(SICI)1096-9098(199610)63:2<112::AID-JSO8>3.0.CO;2-H
Lin J.-D., Chao T.-C., Weng H.-F., Huang H.-S., Ho Y.-S.
Establishment of xenografts and cell lines from well-differentiated human thyroid carcinoma.
J. Surg. Oncol. 63:112-118(1996)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections DSMZ; ACC-360
Cell line databases/resources CCLE; CGTHW1_THYROID
Cosmic-CLP; 910568
GDSC; 910568
Ontologies BTO; BTO:0004740
CLO; CLO_0002406
EFO; EFO_0002131
Biological sample resources BioSample; SAMN03470999
BioSample; SAMN03473318
Chemistry resources ChEMBL-Cells; CHEMBL3308849
ChEMBL-Targets; CHEMBL2366300
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM886926
GEO; GSM887992
GEO; GSM1669673
Other Wikidata; Q54811588
Polymorphism and mutation databases Cosmic; 910568
Cosmic; 1995365
Cosmic; 2054098