Home  |  Contact

Cellosaurus CGTH-W-1 (CVCL_1120)

[Text version]

Cell line name CGTH-W-1
Synonyms CGTH-W1; CGTH W-1; CGTHW1
Accession CVCL_1120
Resource Identification Initiative To cite this cell line use: CGTH-W-1 (RRID:CVCL_1120)
Comments Problematic cell line: Contaminated. Shown to be a SW579 derivative (PubMed=25877200, DSMZ). Originally thought to originate from a thyroid gland follicular carcinoma metastasizing to the sternum of a 70 year old Chinese female patient.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00536.
Doubling time: ~20-25 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for TERT c.228C>T (-124C>T); in promoter (PubMed=23833040).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American2.04
East Asian, North0.24
East Asian, South0
South Asian1.16
European, North64.53
European, South32.03
Disease Thyroid gland squamous cell carcinoma (NCIt: C46008)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3603 (SW579)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO13
D2S133817,18
D3S135815,18
D5S8189,11 (DSMZ)
11 (Cosmic-CLP; PubMed=25877200)
D7S8208,9
D8S117911,13
D13S31713
D16S53911
D18S5115,17
D19S43313,14
D21S1129,31
FGA21,24
Penta D9
Penta E11
TH018,9.3
TPOX8,10
vWA14,18

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=8826082; DOI=10.1007/BF02634562
Lin J.-D., Ho Y.-S., Chang H.-Y., Weng H.-F.
The role of insulin-like growth factor-1 (IGF-1) in follicular thyroid cancer cell line CGTH W-1.
In Vitro Cell. Dev. Biol. Anim. 31:817-821(1995)

PubMed=8888804; DOI=10.1002/(SICI)1096-9098(199610)63:2<112::AID-JSO8>3.0.CO;2-H
Lin J.-D., Chao T.-C., Weng H.-F., Huang H.-S., Ho Y.-S.
Establishment of xenografts and cell lines from well-differentiated human thyroid carcinoma.
J. Surg. Oncol. 63:112-118(1996)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-360
Cell line databases/resources CCLE; CGTHW1_THYROID
Cell_Model_Passport; SIDM01248
Cosmic-CLP; 910568
DepMap; ACH-001023
GDSC; 910568
IGRhCellID; CGTHW1
LINCS_LDP; LCL-1691
Ontologies BTO; BTO:0004740
CLO; CLO_0002406
EFO; EFO_0002131
Biological sample resources BioSample; SAMN03470999
BioSample; SAMN03473318
BioSample; SAMN10987694
Chemistry resources ChEMBL-Cells; CHEMBL3308849
ChEMBL-Targets; CHEMBL2366300
PharmacoDB; CGTHW1_194_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM886926
GEO; GSM887992
GEO; GSM1669673
Other Wikidata; Q54811588
Polymorphism and mutation databases Cosmic; 910568
Cosmic; 1995365
Cosmic; 2054098
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24