Cellosaurus CHL-1 (CVCL_1122)

Cell line name CHL-1
Synonyms CHL1
Accession CVCL_1122
Resource Identification Initiative To cite this cell line use: CHL-1 (RRID:CVCL_1122)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Homozygous for MAPK3 p.Ile228Val (ATCC).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2713 (RPMI-7932)
Children: CVCL_V643 (CHL-2)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S3178,11
D16S53913
D18S5111,12
D19S43313,15
D21S1129,30
D2S133818
D3S135815,17
D5S81811,12
D7S82011,13
D8S117910,13
FGA23,25
Penta D12,14
Penta E10,13
TH019,9.3
TPOX8
vWA17
Publications

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-9446
Cell line databases/resources CCLE; CHL1_SKIN
Cosmic-CLP; 910853
GDSC; 910853
IGRhCellID; CHL1
Ontologies BTO; BTO:0004061
CLO; CLO_0002420
EFO; EFO_0002132
Biological sample resources BioSample; SAMN03470897
Chemistry resources ChEMBL-Cells; CHEMBL3308722
ChEMBL-Targets; CHEMBL1075422
Gene expression databases GEO; GSM886928
GEO; GSM887994
GEO; GSM1669675
Polymorphism and mutation databases Cosmic; 706115
Cosmic; 897494
Cosmic; 910853
Cosmic; 1459665
Cosmic; 1477418
Cosmic; 1995367