Cellosaurus CHP-134 (CVCL_1124)

Cell line name CHP-134
Synonyms CHP 134; CHP_134; CHP134
Accession CVCL_1124
Resource Identification Initiative To cite this cell line use: CHP-134 (RRID:CVCL_1124)
Comments Doubling time: 57.6 hours (PubMed=10079); ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Neuroblastoma (NCIt: C3270)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; RCB

Markers:
AmelogeninX,Y
CSF1PO9,12 (Cosmic-CLP; RCB)
9,13 (DSMZ; ECACC)
D13S3178,11
D16S53911,13 (Cosmic-CLP; DSMZ; ECACC)
11 (RCB)
D5S81811,12
D7S8209
TH019,9.3
TPOX8
vWA18,19
Publications

PubMed=10079
Schlesinger H.R., Gerson J.M., Moorhead P.S., Maguire H., Hummeler K.
Establishment and characterization of human neuroblastoma cell lines.
Cancer Res. 36:3094-3100(1976)

PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4
Gilbert F., Balaban G., Moorhead P.S., Bianchi D., Schlesinger H.R.
Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.
Cancer Genet. Cytogenet. 7:33-42(1982)

PubMed=6888561; DOI=10.1038/305245a0
Schwab M., Alitalo K., Klempnauer K.-H., Varmus H.E., Bishop J.M., Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=12702577
Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references
Cell line collections DSMZ; ACC-653
ECACC; 06122002
RCB; RCB0487
Cell line databases/resources CGH-DB; 75-1
CGH-DB; 9099-4
Cosmic-CLP; 910941
GDSC; 910941
Ontologies BTO; BTO:0002989
CLO; CLO_0051417
Biological sample resources BioSample; SAMN03472330
BioSample; SAMN03473466
Chemistry resources ChEMBL-Cells; CHEMBL3308253
ChEMBL-Targets; CHEMBL2366128
Gene expression databases GEO; GSM313800
GEO; GSM333795
GEO; GSM563356
GEO; GSM692863
GEO; GSM1366404
GEO; GSM1669677
GEO; GSM2371222
GEO; GSM2394376
Polymorphism and mutation databases Cosmic; 688063
Cosmic; 801744
Cosmic; 848934
Cosmic; 910941
Cosmic; 920253
Cosmic; 930063
Cosmic; 947707
Cosmic; 1019934
Cosmic; 1037353
Cosmic; 1099150
Cosmic; 1109362
Cosmic; 1153779
Cosmic; 1161986
Cosmic; 1526620
Cosmic; 2131592
Cosmic; 2393629
Cosmic; 2485943