ID   CHP-134
AC   CVCL_1124
SY   CHP 134; CHP_134; CHP134; Children's Hospital of Philadelphia-134
DR   BTO; BTO:0002989
DR   CLO; CLO_0051417
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03472330
DR   BioSample; SAMN03473466
DR   cancercelllines; CVCL_1124
DR   Cell_Model_Passport; SIDM00285
DR   CGH-DB; 75-1
DR   CGH-DB; 9099-4
DR   ChEMBL-Cells; CHEMBL3308253
DR   ChEMBL-Targets; CHEMBL2366128
DR   Cosmic; 688063
DR   Cosmic; 801744
DR   Cosmic; 848934
DR   Cosmic; 910941
DR   Cosmic; 920253
DR   Cosmic; 930063
DR   Cosmic; 947707
DR   Cosmic; 1019934
DR   Cosmic; 1037353
DR   Cosmic; 1099150
DR   Cosmic; 1109362
DR   Cosmic; 1153779
DR   Cosmic; 1161986
DR   Cosmic; 1526620
DR   Cosmic; 2131592
DR   Cosmic; 2393629
DR   Cosmic; 2485943
DR   Cosmic-CLP; 910941
DR   DepMap; ACH-001338
DR   DSMZ; ACC-653
DR   DSMZCellDive; ACC-653
DR   ECACC; 06122002
DR   EGA; EGAS00001000978
DR   GDSC; 910941
DR   GEO; GSM313800
DR   GEO; GSM333795
DR   GEO; GSM563356
DR   GEO; GSM692863
DR   GEO; GSM1366404
DR   GEO; GSM1669677
DR   GEO; GSM2371222
DR   GEO; GSM2394376
DR   GEO; GSM3145699
DR   IARC_TP53; 21226
DR   PharmacoDB; CHP134_199_2019
DR   Progenetix; CVCL_1124
DR   PubChem_Cell_line; CVCL_1124
DR   RCB; RCB0487
DR   Wikidata; Q54813265
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=10079;
RX   PubMed=6888561;
RX   PubMed=7139592;
RX   PubMed=12702577;
RX   PubMed=15892104;
RX   PubMed=16822308;
RX   PubMed=18724359;
RX   PubMed=18923524;
RX   PubMed=20164919;
RX   PubMed=22213050;
RX   PubMed=23202128;
RX   PubMed=24466371;
RX   PubMed=27397505;
RX   PubMed=28350380;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: 57.6 hours (PubMed=10079); ~30 hours (DSMZ=ACC-653).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.04%; Native American=0%; East Asian, North=0.15%; East Asian, South=0%; South Asian=0.93%; European, North=70.26%; European, South=28.62% (PubMed=30894373).
CC   Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
ST   Source(s): Cosmic-CLP; DepMap; DSMZ; ECACC; RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 9,12 (Cosmic-CLP; RCB)
ST   CSF1PO: 9,13 (DepMap; DSMZ; ECACC)
ST   D13S317: 8,10,11 (DepMap)
ST   D13S317: 8,11 (Cosmic-CLP; DSMZ; ECACC; RCB)
ST   D16S539: 11 (RCB)
ST   D16S539: 11,13 (Cosmic-CLP; DepMap; DSMZ; ECACC)
ST   D18S51: 15,18
ST   D19S433: 12,13
ST   D21S11: 28,29
ST   D2S1338: 20,27
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 9
ST   D8S1179: 8,14 (DepMap)
ST   D8S1179: 14 (DSMZ)
ST   FGA: 21,25
ST   Penta D: 9
ST   Penta E: 5,7
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 18,19
DI   NCIt; C4827; Adrenal gland neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   1Y1M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 36
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=10079;
RA   Schlesinger H.R., Gerson J.M., Moorhead P.S., Maguire H., Hummeler K.;
RT   "Establishment and characterization of human neuroblastoma cell
RT   lines.";
RL   Cancer Res. 36:3094-3100(1976).
//
RX   PubMed=6888561; DOI=10.1038/305245a0;
RA   Schwab M., Alitalo K., Klempnauer K.-H., Varmus H.E., Bishop J.M.,
RA   Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.;
RT   "Amplified DNA with limited homology to myc cellular oncogene is
RT   shared by human neuroblastoma cell lines and a neuroblastoma tumour.";
RL   Nature 305:245-248(1983).
//
RX   PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4;
RA   Gilbert F., Balaban G.B., Moorhead P.S., Bianchi D., Schlesinger H.R.;
RT   "Abnormalities of chromosome 1p in human neuroblastoma tumors and cell
RT   lines.";
RL   Cancer Genet. Cytogenet. 7:33-42(1982).
//
RX   PubMed=12702577;
RA   Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A.,
RA   Sugimoto T., Inazawa J.;
RT   "PPM1D is a potential target for 17q gain in neuroblastoma.";
RL   Cancer Res. 63:1876-1883(2003).
//
RX   PubMed=15892104; DOI=10.1002/gcc.20198;
RA   Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D.,
RA   Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L.,
RA   Maris J.M.;
RT   "High-resolution detection and mapping of genomic DNA alterations in
RT   neuroblastoma.";
RL   Genes Chromosomes Cancer 43:390-403(2005).
//
RX   PubMed=16822308; DOI=10.1186/1471-2407-6-177;
RA   Dam V., Morgan B.T., Mazanek P., Hogarty M.D.;
RT   "Mutations in PIK3CA are infrequent in neuroblastoma.";
RL   BMC Cancer 6:177.1-177.10(2006).
//
RX   PubMed=18724359; DOI=10.1038/nature07261;
RA   Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A.,
RA   Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P.,
RA   Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A.,
RA   Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M.,
RA   Maris J.M.;
RT   "Identification of ALK as a major familial neuroblastoma
RT   predisposition gene.";
RL   Nature 455:930-935(2008).
//
RX   PubMed=18923524; DOI=10.1038/nature07399;
RA   Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M.,
RA   Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A.,
RA   Hayashi Y., Mano H., Ogawa S.;
RT   "Oncogenic mutations of ALK kinase in neuroblastoma.";
RL   Nature 455:971-974(2008).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22213050; DOI=10.1002/ijc.27415;
RA   Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J.,
RA   Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.;
RT   "PEA15 impairs cell migration and correlates with clinical features
RT   predicting good prognosis in neuroblastoma.";
RL   Int. J. Cancer 131:1556-1568(2012).
//
RX   PubMed=23202128; DOI=10.1038/ng.2493;
RA   Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y.,
RA   Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.;
RT   "Integrated genomic analyses identify ARID1A and ARID1B alterations in
RT   the childhood cancer neuroblastoma.";
RL   Nat. Genet. 45:12-17(2013).
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544;
RA   Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J.,
RA   Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A.,
RA   Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.;
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33;
RA   Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L.,
RA   Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.;
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033-170033(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//