Cell line name | CML-T1 | ||||||||||||||||||
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Synonyms | CML T1; CMLT-1; CMLT1 | ||||||||||||||||||
Accession | CVCL_1126 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: CML-T1 (RRID:CVCL_1126) | ||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: LL-100 blood cancer cell line panel. Population: Japanese. Doubling time: ~48-60 hours (DSMZ). Microsatellite instability: Instable (MSI-low) (PubMed=31068700; Sanger). Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Peripheral blood. | ||||||||||||||||||
Sequence variations | Gene fusion; BCR-ABL1 (DepMap).Heterozygous for PTEN p.Thr321fs*23 (c.963delA) (CCLE; Cosmic-CLP).Heterozygous for TP53 p.Arg181Cys (c.541C>T) (ClinVar=VCV000142624) (CCLE).Heterozygous for TP53 p.Arg290Cys (c.868C>T) (ClinVar=VCV000216472) (CCLE). | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521) | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Sex of cell | Female | ||||||||||||||||||
Age at sampling | 36Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): Cosmic-CLP; DSMZ Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=2788468; DOI=10.1182/blood.V74.4.1381.1381 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=17170727; DOI=10.1038/sj.leu.2404486 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=22460905; DOI=10.1038/nature11003 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=30285677; DOI=10.1186/s12885-018-4840-5 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31160637; DOI=10.1038/s41598-019-44491-x | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | DSMZ; ACC-7 | ||||||||||||||||||
Cell line databases/resources | CLDB; cl815
CCLE; CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE Cell_Model_Passport; SIDM00958 Cosmic-CLP; 910951 DepMap; ACH-000920 IGRhCellID; CMLT1 | ||||||||||||||||||
Ontologies | CLO; CLO_0002527
EFO; EFO_0002134 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03473449
BioSample; SAMN10988485 | ||||||||||||||||||
Chemistry resources | GDSC; 910951
PharmacoDB; CMLT1_213_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 ArrayExpress; E-MTAB-7721 ArrayExpress; E-MTAB-7722 GEO; GSM886939 GEO; GSM888006 GEO; GSM1669682 | ||||||||||||||||||
Other | Wikidata; Q54813803 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 910951
Cosmic; 913424 Cosmic; 1012062 Cosmic; 1026574 Cosmic; 1151775 IARC_TP53; 21229 IARC_TP53; 30192 LiGeA; CCLE_639 Progenetix; CVCL_1126 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||
Version number | 26 |