Cellosaurus CML-T1 (CVCL_1126)

Cell line name CML-T1
Synonyms CML T1; CMLT1; CMLT-1
Accession CVCL_1126
Resource Identification Initiative To cite this cell line use: CML-T1 (RRID:CVCL_1126)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~48-60 hours (DSMZ).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D13S31710,13 (Cosmic-CLP)
10,13,14 (DSMZ)
D16S53910,11 (Cosmic-CLP)
10,11,12 (DSMZ)
D5S8189,11
D7S8208,11
TH017,9
TPOX8,11
vWA16,20
Publications

PubMed=2788468
Kuriyama K., Gale R.P., Tomonaga M., Ikeda S., Yao E., Klisak I., Whelan K., Yakir H., Ichimaru M., Sparkes R.S., Dreazen O.
CML-T1: a cell line derived from T-lymphocyte acute phase of chronic myelogenous leukemia.
Blood 74:1381-1387(1989)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-7
Cell line databases/resources CLDB; cl815
CCLE; CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 910951
GDSC; 910951
IGRhCellID; CMLT1
Ontologies CLO; CLO_0002527
EFO; EFO_0002134
Biological sample resources BioSample; SAMN03473449
Gene expression databases GEO; GSM886939
GEO; GSM888006
GEO; GSM1669682
Polymorphism and mutation databases Cosmic; 910951
Cosmic; 913424
Cosmic; 1012062
Cosmic; 1026574
Cosmic; 1151775