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Cellosaurus COLO 668 (CVCL_1128)

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Cell line name COLO 668
Synonyms Colo 668; COLO-668; COLO668
Accession CVCL_1128
Resource Identification Initiative To cite this cell line use: COLO 668 (RRID:CVCL_1128)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: NCI RAS program mutant KRAS cell line panel.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations BRAF p.Val600Glu (c.1799T>A) (PubMed=18397470).
Homozygous for KRAS p.Gly12Val (c.35G>T) (CCLE; Cosmic-CLP).
Heterozygous for RB1 p.Leu337fs*12 (c.1006delT) and p.Gln436Ter (c.1306C>T) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Gly245Cys (c.733G>T) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.4
Native American16.55
East Asian, North3.63
East Asian, South0
South Asian3.09
European, North28.55
European, South45.77
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Brain.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC

Markers:
AmelogeninX
CSF1PO10
D5S81811
D7S8208,10 (Cosmic-CLP)
8.2,10 (ECACC)
D13S31710,11
D16S53911,12
TH019
TPOX8,11 (Cosmic-CLP)
8 (ECACC)
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S., Nakagawa K., Nomura H., Ishikawa Y.
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=18397470; DOI=10.1111/j.1749-0774.2008.00046.x
Ueda M., Toji E., Nunobiki O., Izuma S., Okamoto Y., Torii K., Noda S.
Mutational analysis of the BRAF gene in human tumor cells.
Hum. Cell 21:13-17(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ECACC; 87061209
Cell line databases/resources CLDB; cl835
CCLE; COLO668_LUNG
Cell_Model_Passport; SIDM00143
Cosmic-CLP; 910692
DepMap; ACH-000803
GDSC; 910692
LINCS_LDP; LCL-1867
Ontologies CLO; CLO_0002549
EFO; EFO_0002138
Biological sample resources BioSample; SAMN10987711
Chemistry resources ChEMBL-Cells; CHEMBL3308864
ChEMBL-Targets; CHEMBL2366215
PharmacoDB; COLO668_224_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM17195
GEO; GSM886942
GEO; GSM888009
GEO; GSM1669686
Other Wikidata; Q54814129
Polymorphism and mutation databases Cosmic; 877393
Cosmic; 910692
Cosmic; 1152488
Cosmic; 1995370
IARC_TP53; 21231
LiGeA; CCLE_861
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22