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Cellosaurus COLO 824 (CVCL_1136)

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Cell line name COLO 824
Synonyms Colo 824; COLO-824; Colo-824; COLO824; Colo824
Accession CVCL_1136
Resource Identification Initiative To cite this cell line use: COLO 824 (RRID:CVCL_1136)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: GrayJW Breast Cancer Cell Line Panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~60-80 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: Previously erroneously indicated as originating from a male patient, correct gender assignment from Moore G.E. in a personal communication to the authors of PubMed=9892114.
Genome ancestry Source: PubMed=30894373

Origin% genome
African85.4
Native American0.04
East Asian, North1.28
East Asian, South0
South Asian0
European, North5.62
European, South7.67
Disease Breast carcinoma (NCIt: C4872)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D3S135816,17
D5S81812
D7S8208,11 (CLS; Cosmic-CLP; DSMZ)
7.9,8,11 (PubMed=25877200)
D8S117912,14
D13S31711,12,13
D16S53913 (CLS; Cosmic-CLP; PubMed=25877200)
12,13 (DSMZ)
D18S5115,19
D21S1128
FGA22
Penta D5,10
Penta E7
TH017,9
TPOX6,11
vWA16

Run an STR similarity search on this cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
http://tcpaportal.org/mclp/
Publications

PubMed=9892114; DOI=10.1002/(SICI)1098-2264(199901)24:1<87::AID-GCC13>3.0.CO;2-5
Savelyeva L., Claas A., An H., Weber R.G., Lichter P., Schwab M.
Retention of polysomy at 9p23-24 during karyotypic evolution in human breast cancer cell line COLO 824.
Genes Chromosomes Cancer 24:87-93(1999)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections CLS; 300463/p815_Colo-824
DSMZ; ACC-200
Cell line databases/resources CLDB; cl870
CCLE; COLO824_BREAST
Cell_Model_Passport; SIDM00954
Cosmic-CLP; 906812
DepMap; ACH-001820
LINCS_LDP; LCL-1477
Ontologies CLO; CLO_0002577
Biological sample resources BioSample; SAMN03471347
BioSample; SAMN03473374
Chemistry resources ChEMBL-Cells; CHEMBL3308725
ChEMBL-Targets; CHEMBL1075430
GDSC; 906812
PharmacoDB; COLO824_237_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM718287
GEO; GSM783979
GEO; GSM847249
GEO; GSM847459
GEO; GSM843492
GEO; GSM843493
GEO; GSM1669694
Other Wikidata; Q54814156
Polymorphism and mutation databases Cosmic; 906812
Entry history
Entry creation04-Apr-2012
Last entry updated19-Dec-2019
Version number25