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Cellosaurus COR-L23 (CVCL_1139)

Cell line name COR-L23
Synonyms CORL23; COR-L23/P; L23/P
Accession CVCL_1139
Resource Identification Initiative To cite this cell line use: COR-L23 (RRID:CVCL_1139)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 35 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Large cell lung carcinoma (NCIt: C4450)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2006 (COR-L23/5010)CVCL_2007 (COR-L23/CPR)CVCL_2008 (COR-L23/R)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC

Markers:
AmelogeninX (Cosmic-CLP)
X,Y (ECACC)
CSF1PO11
D13S31710,11
D16S53911,13
D5S81810,12
D7S8209
TH019
TPOX8,11
vWA19
Publications

PubMed=2998422; DOI=10.1038/bjc.1985.220
Baillie-Johnson H., Twentyman P.R., Fox N.E., Walls G.A., Workman P., Watson J.V., Johnson N., Reeve J.G., Bleehen N.M.
Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma).
Br. J. Cancer 52:495-504(1985)

PubMed=3034934; DOI=10.1002/jcb.240330405
Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.
Oncogene amplification and chromosomal abnormalities in small cell lung cancer.
J. Cell. Biochem. 33:267-288(1987)

PubMed=7903701; DOI=10.1093/jnci/86.2.110
Barrand M.A., Heppell-Parton A.C., Wright K.A., Rabbitts P.H., Twentyman P.R.
A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene.
J. Natl. Cancer Inst. 86:110-117(1994)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ECACC; 92031919
ICLC; HTL95012
Cell line databases/resources CLDB; cl877
CLDB; cl878
CCLE; CORL23_LUNG
Cosmic-CLP; 687780
GDSC; 687780
IGRhCellID; CORL23
LINCS_LDP; LCL-1780
Ontologies CLO; CLO_0002585
EFO; EFO_0002142
Chemistry resources ChEMBL-Cells; CHEMBL3308073
ChEMBL-Targets; CHEMBL613854
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM784278
GEO; GSM827427
GEO; GSM886956
GEO; GSM888024
GEO; GSM1669697
Other Wikidata; Q54814270
Polymorphism and mutation databases Cosmic; 687780
Cosmic; 1995378