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Cellosaurus CTV-1 (CVCL_1150)

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Cell line name CTV-1
Synonyms CTV1
Accession CVCL_1150
Resource Identification Initiative To cite this cell line use: CTV-1 (RRID:CVCL_1150)
Comments Problematic cell line: Probably misidentified. Originally thought to be a acute monoblastic leukemia but seems to be a T-ALL cell line (PubMed=15843827). Was also said to originate from a 40 year old female patient (PubMed=6593267) but has a male STR profile.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~36 hours (PubMed=6593267); ~40 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: CTY-1; In Cosmic 717685 and PubMed=9379676.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FBXW7 p.Gly477Ser (c.1429G>A) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for FLT3 p.Gly831Glu (c.2492G>A) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for LCK p.Ala353Val (c.1058C>T) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for LCK p.Pro447Leu (c.1340C>T) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for LCK p.Ala500Thr (c.1498G>A) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for NF1 p.Gly1532Arg (c.4594G>A) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for NOTCH1 p.Ser2523Ter (c.7568C>A) (CCLE; Cosmic-CLP).
Heterozygous for PDGFRB p.Met772Ile (c.2316G>A) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for RET p.Cys656Phe (c.1967G>T) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for STK11 p.Arg75Met (c.224G>T) (PubMed=22675565; CCLE; Cosmic-CLP).
Heterozygous for STK11 p.Lys175Met (c.524A>T) (PubMed=22675565; CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.28
East Asian, North0
East Asian, South0.34
South Asian5.64
European, North45.18
European, South46.55
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8150 (MOLT-15)
Originate from same individual CVCL_RX77 ! CTV-2
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

vWA17,18 (DSMZ)
18,19 (Cosmic-CLP)

Run an STR similarity search on this cell line

PubMed=6593267; DOI=10.20772/cancersci1959.75.8_660
Chen P.-M., Chiu C.-F., Chiou T.-J., Maeda S., Chiang H., Tzeng C.-H., Sugiyama T., Chiang B.N.
Establishment and characterization of a human monocytoid leukemia cell line, CTV-1.
Gann 75:660-664(1984)

Drexler H.G., Gaedicke G., Maeda S., Chen P.-M., Minowada J.
Monocytoid leukemia cell line CTV-1: morphological, immunological and isoenzymatic characteristics.
Tumor Biol. 6:503-517(1986)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Sheng X.-M., Kawamura M., Ohnishi H., Ida K., Hanada R., Kojima S., Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections DSMZ; ACC-40
Cell line databases/resources CLDB; cl927
Cell_Model_Passport; SIDM00951
Cosmic-CLP; 753548
DepMap; ACH-002222
Ontologies CLO; CLO_0002638
Biological sample resources BioSample; SAMN03473579
Chemistry resources ChEMBL-Cells; CHEMBL3308189
ChEMBL-Targets; CHEMBL2366360
GDSC; 753548
PharmacoDB; CTV1_268_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1374458
GEO; GSM1669712
Other Wikidata; Q54814774
Polymorphism and mutation databases Cosmic; 717685
Cosmic; 753548
Cosmic; 787426
Cosmic; 947372
Cosmic; 975244
Cosmic; 998755
Cosmic; 1078737
Cosmic; 1151776
Cosmic; 1524794
Cosmic; 1760520
Cosmic; 2089657
Cosmic; 2131536
Cosmic; 2306203
IARC_TP53; 21259
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number30