Cellosaurus CTV-1 (CVCL_1150)

Cell line name CTV-1
Synonyms CTV1
Accession CVCL_1150
Resource Identification Initiative To cite this cell line use: CTV-1 (RRID:CVCL_1150)
Comments Problematic cell line: Probably misidentified. Originally thought to be a acute monoblastic leukemia but seems to be a T-ALL cell line (PubMed=15843827). Was also said to originate from a 40 year old female patient (PubMed=6593267) but has a male STR profile.
Part of: COSMIC cell lines project.
Doubling time: ~36 hours (PubMed=6593267); ~40 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Misspelling: CTY-1; In Cosmic 717685 and PubMed=9379676.
Derived from sampling site: Peripheral blood.
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8150 (MOLT-15)
Originate from same individual CVCL_RX77 ! CTV-2
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

vWA18,19 (Cosmic-CLP)
17,18 (DSMZ)

PubMed=6593267; DOI=10.20772/cancersci1959.75.8_660
Chen P.-M., Chiu C.-F., Chiou T.-J., Maeda S., Chiang H., Tzeng C.-H., Sugiyama T., Chiang B.-N.
Establishment and characterization of a human monocytoid leukemia cell line, CTV-1.
Gann 75:660-664(1984)

Drexler H.G., Gaedicke G., Maeda S., Chen P.-M., Minowada J.
Monocytoid leukemia cell line CTV-1: morphological, immunological and isoenzymatic characteristics.
Tumor Biol. 6:503-517(1986)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Sheng X.-M., Kawamura M., Ohnishi H., Ida K., Hanada R., Kojima S., Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections DSMZ; ACC-40
Cell line databases/resources CLDB; cl927
Cosmic-CLP; 753548
GDSC; 753548
Ontologies CLO; CLO_0002638
Biological sample resources BioSample; SAMN03473579
Chemistry resources ChEMBL-Cells; CHEMBL3308189
ChEMBL-Targets; CHEMBL2366360
Gene expression databases GEO; GSM1374458
GEO; GSM1669712
Polymorphism and mutation databases Cosmic; 717685
Cosmic; 753548
Cosmic; 787426
Cosmic; 975244
Cosmic; 998755
Cosmic; 1078737
Cosmic; 1151776
Cosmic; 1524794
Cosmic; 1760520
Cosmic; 2089657
Cosmic; 2131536
Cosmic; 2306203