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Cellosaurus D-245MG (CVCL_1152)

[Text version]

Cell line name D-245MG
Synonyms D-245 MG; D245 MG; D245MG
Accession CVCL_1152
Resource Identification Initiative To cite this cell line use: D-245MG (RRID:CVCL_1152)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.72
Native American1.42
East Asian, North0.26
East Asian, South0.81
South Asian1.32
European, North65.72
European, South28.76
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81813
D7S8209,12
D13S31712,13
D16S53912
TH018,9
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=2881426; DOI=10.1007/BF00687952
Bigner S.H., Friedman H.S., Biegel J.A., Wikstrand C.J., Mark J., Gebhardt R., Eng L.F., Bigner D.D.
Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas.
Acta Neuropathol. 72:86-97(1986)

PubMed=2253244
Bigner S.H., Humphrey P.A., Wong A.J., Vogelstein B., Mark J., Friedman H.S., Bigner D.D.
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.
Cancer Res. 50:8017-8022(1990)

PubMed=9220028; DOI=10.1016/S0303-7207(97)00080-4
Sharif T.R., Luo W., Sharif M.
Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.
Mol. Cell. Endocrinol. 130:119-130(1997)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; D245MG_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM01021
Cosmic-CLP; 946366
DepMap; ACH-002223
Gene expression databases GEO; GSM1669714
Other Wikidata; Q54817123
Polymorphism and mutation databases Cosmic; 946366
Cosmic; 2367512
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number18