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Cellosaurus D-247MG (CVCL_1153)

[Text version]

Cell line name D-247MG
Synonyms D-247 MG; D-247-MG; D247MG
Accession CVCL_1153
Resource Identification Initiative To cite this cell line use: D-247MG (RRID:CVCL_1153)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: D24.7; In PubMed=11351043.
Sequence variations Homozygous for PTEN c.210-1G>C; splice acceptor mutation (CCLE; Cosmic-CLP).
Has no TP53 mutation (PubMed=14614447).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.5
East Asian, North0
East Asian, South0
South Asian1.46
European, North67.83
European, South30.2
Disease Gliosarcoma (NCIt: C3796)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=22570425

Markers:
AmelogeninX
CSF1PO9,11
D3S135817,18
D5S81810,12
D7S8209,13
D8S117915
D13S3178,10
D16S5399,12
D18S5115,17
D21S1130
FGA24,27
Penta D11,12
Penta E13,18
TH016,9
TPOX9,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=2881426; DOI=10.1007/BF00687952
Bigner S.H., Friedman H.S., Biegel J.A., Wikstrand C.J., Mark J., Gebhardt R., Eng L.F., Bigner D.D.
Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas.
Acta Neuropathol. 72:86-97(1986)

PubMed=9220028; DOI=10.1016/S0303-7207(97)00080-4
Sharif T.R., Luo W., Sharif M.
Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.
Mol. Cell. Endocrinol. 130:119-130(1997)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x
Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=11351043; DOI=10.1038/labinvest.3780280
Hui A.B.-Y., Lo K.-W., Yin X.-L., Poon W.-S., Ng H.-K.
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization.
Lab. Invest. 81:717-723(2001)

PubMed=14614447; DOI=10.1038/sj.onc.1207198
Wischhusen J., Naumann U., Ohgaki H., Rastinejad F., Weller M.
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.
Oncogene 22:8233-8245(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; D247MG_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00622
Cosmic-CLP; 946367
DepMap; ACH-002224
GDSC; 946367
LINCS_LDP; LCL-1370
Chemistry resources ChEMBL-Cells; CHEMBL3308542
ChEMBL-Targets; CHEMBL2366237
PharmacoDB; D247MG_271_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669715
Other Wikidata; Q54817124
Polymorphism and mutation databases Cosmic; 849881
Cosmic; 946367
Cosmic; 2367513
IARC_TP53; 27689
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23