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Cellosaurus D-263MG (CVCL_1154)

[Text version]

Cell line name D-263MG
Synonyms D-263 MG; D263MG
Accession CVCL_1154
Resource Identification Initiative To cite this cell line use: D-263MG (RRID:CVCL_1154)
Comments Problematic cell line: Possibly misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (STR profile).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.41
Native American1.08
East Asian, North0.75
East Asian, South0
South Asian2.84
European, North63.92
European, South31.01
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811
D7S82010
D13S31714
D16S53911,12
TH018,9.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=2881426; DOI=10.1007/BF00687952
Bigner S.H., Friedman H.S., Biegel J.A., Wikstrand C.J., Mark J., Gebhardt R., Eng L.F., Bigner D.D.
Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas.
Acta Neuropathol. 72:86-97(1986)

PubMed=3011240; DOI=10.1016/0165-4608(86)90172-X
Bigner S.H., Mark J., Bullard D.E., Mahaley M.S. Jr., Bigner D.D.
Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations.
Cancer Genet. Cytogenet. 22:121-135(1986)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; D263MG_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00732
Cosmic-CLP; 946368
DepMap; ACH-002225
GDSC; 946368
LINCS_LDP; LCL-1371
Chemistry resources ChEMBL-Cells; CHEMBL3308255
ChEMBL-Targets; CHEMBL2366183
PharmacoDB; D263MG_272_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669716
Other Wikidata; Q54817126
Polymorphism and mutation databases Cosmic; 946368
Cosmic; 2367514
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22