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Cellosaurus D283 Med (CVCL_1155)

[Text version]

Cell line name D283 Med
Synonyms D283 MED; D283-MED; D-283 Med; D-283MED; D283MED; D283Med; D283-Med; D-283; D283; Med 283; H283
Accession CVCL_1155
Resource Identification Initiative To cite this cell line use: D283 Med (RRID:CVCL_1155)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: D283 MR; Occasionally.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.87
Native American0
East Asian, North1.34
East Asian, South0
South Asian0
European, North63.61
European, South33.18
Disease Medulloblastoma (NCIt: C3222)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133817,23
D3S135815
D5S81811
D7S82010
D8S117912,13
D13S3178,10
D16S53911
D19S43313,14
D21S1128,30.2
FGA20,23
TH017
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=1530
Publications

PubMed=4056828; DOI=10.1097/00005072-198511000-00005
Friedman H.S., Burger P.C., Bigner S.H., Trojanowski J.Q., Wikstrand C.J., Halperin E.C., Bigner D.D.
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.
J. Neuropathol. Exp. Neurol. 44:592-605(1985)

PubMed=3103453
Trojanowski J.Q., Friedman H.S., Burger P.C., Bigner D.D.
A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.
Am. J. Pathol. 126:358-363(1987)

PubMed=1822845
Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=12973738; DOI=10.1002/pmic.200300460
Peyrl A., Krapfenbauer K., Slavc I., Yang J.-W., Strobel T., Lubec G.
Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.
Proteomics 3:1781-1800(2003)

PubMed=16946619; DOI=10.1159/000095545
Dharmaraj P., Ball S., Johnstone H., Bailey S., Clifford S.C., Hale J., Cheetham T.D.
Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis evidence to support PTHrP production by medulloblastoma cells.
Horm. Res. 66:268-272(2006)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuonc/noq179
Weeraratne S.D., Amani V., Neiss A., Teider N., Scott D.K., Pomeroy S.L., Cho Y.-J.
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Neuro-oncol. 13:165-175(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281
Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=24300787; DOI=10.1158/1078-0432.CCR-13-2053
Erdreich-Epstein A., Robison N., Ren X., Zhou H., Xu J., Davidson T.B., Schur M., Gilles F.H., Ji L., Malvar J., Shackleford G.M., Margol A.S., Krieger M.D., Judkins A.R., Jones D.T.W., Pfister S.M., Kool M., Sposto R., Asgharzadeh S.
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Clin. Cancer Res. 20:827-836(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: Choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31963405; DOI=10.3390/cancers12010226
Casciati A., Tanori M., Manczak R., Saada S., Tanno B., Giardullo P., Porcu E., Rampazzo E., Persano L., Viola G., Dalmay C., Lalloue F., Pothier A., Merla C., Mancuso M.
Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
Cancers (Basel) 12:226.1-226.14(2020)

Cross-references
Cell line collections ATCC; HTB-185
IZSLER; BS TCL 203
Cell line databases/resources CCLE; D283MED_CENTRAL_NERVOUS_SYSTEM
CCRID; 3111C0001CCC000341
Cell_Model_Passport; SIDM00888
Cosmic-CLP; 906834
DepMap; ACH-000055
IGRhCellID; D283Med
LINCS_LDP; LCL-1577
Lonza; 654
Ontologies BTO; BTO:0005135
CLO; CLO_0002673
EFO; EFO_0002156
Biological sample resources BioSample; SAMN03472736
BioSample; SAMN10987924
Chemistry resources ChEMBL-Cells; CHEMBL3307938
ChEMBL-Targets; CHEMBL614476
GDSC; 906834
PharmacoDB; D283MED_273_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM482336
GEO; GSM886969
GEO; GSM888038
GEO; GSM918116
GEO; GSM919357
GEO; GSM1234974
GEO; GSM1234975
GEO; GSM1669717
Other Wikidata; Q54817202
Polymorphism and mutation databases Cosmic; 687772
Cosmic; 906834
Cosmic; 923656
Cosmic; 973261
Cosmic; 974280
Cosmic; 975024
Cosmic; 1995381
Cosmic; 2362650
LiGeA; CCLE_487
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number29