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Cellosaurus D283 Med (CVCL_1155)

[Text version]

Cell line name D283 Med
Synonyms D283 MED; D283-MED; D-283 Med; D-283MED; D283MED; D283Med; D283-Med; D283; Med 283; H283
Accession CVCL_1155
Resource Identification Initiative To cite this cell line use: D283 Med (RRID:CVCL_1155)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: D283 MR; Occasionally.
Disease Medulloblastoma (NCIt: C3222)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO9,12
D5S81811
D7S82010
D13S3178,10
D16S53911
TH017
TPOX8,11
vWA16,18
Publications

PubMed=4056828; DOI=10.1097/00005072-198511000-00005
Friedman H.S., Burger P.C., Bigner S.H., Trojanowski J.Q., Wikstrand C.J., Halperin E.C., Bigner D.D.
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.
J. Neuropathol. Exp. Neurol. 44:592-605(1985)

PubMed=3103453
Trojanowski J.Q., Friedman H.S., Burger P.C., Bigner D.D.
A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.
Am. J. Pathol. 126:358-363(1987)

PubMed=1822845
Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=12973738; DOI=10.1002/pmic.200300460
Peyrl A., Krapfenbauer K., Slavc I., Yang J.-W., Strobel T., Lubec G.
Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.
Proteomics 3:1781-1800(2003)

PubMed=16946619; DOI=10.1159/000095545
Dharmaraj P., Ball S., Johnstone H., Bailey S., Clifford S.C., Hale J., Cheetham T.D.
Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis evidence to support PTHrP production by medulloblastoma cells.
Horm. Res. 66:268-272(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24300787; DOI=10.1158/1078-0432.CCR-13-2053
Erdreich-Epstein A., Robison N., Ren X., Zhou H., Xu J., Davidson T.B., Schur M., Gilles F.H., Ji L., Malvar J., Shackleford G.M., Margol A.S., Krieger M.D., Judkins A.R., Jones D.T.W., Pfister S.M., Kool M., Sposto R., Asgharzadeh S.
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Clin. Cancer Res. 20:827-836(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; HTB-185
IZSLER; BS TCL 203
Cell line databases/resources CCLE; D283MED_CENTRAL_NERVOUS_SYSTEM
CCRID; 3111C0001CCC000341
Cell_Model_Passport; SIDM00888
Cosmic-CLP; 906834
GDSC; 906834
IGRhCellID; D283Med
LINCS_LDP; LCL-1577
Lonza; 654
Ontologies BTO; BTO:0005135
CLO; CLO_0002673
EFO; EFO_0002156
Biological sample resources BioSample; SAMN03472736
Chemistry resources ChEMBL-Cells; CHEMBL3307938
ChEMBL-Targets; CHEMBL614476
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM482336
GEO; GSM886969
GEO; GSM888038
GEO; GSM918116
GEO; GSM919357
GEO; GSM1669717
Other Wikidata; Q54817202
Polymorphism and mutation databases Cosmic; 687772
Cosmic; 906834
Cosmic; 923656
Cosmic; 973261
Cosmic; 974280
Cosmic; 975024
Cosmic; 1995381
Cosmic; 2362650