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Cellosaurus Daoy (CVCL_1167)

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Cell line name Daoy
Synonyms DAOY; D324 Med; D-324 Med; D324 MED; D-324MED; D324
Accession CVCL_1167
Secondary accession CVCL_7903
Resource Identification Initiative To cite this cell line use: Daoy (RRID:CVCL_1167)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 33.6 hours, at 48th passage (PubMed=2993532); 34 hours (ATCC).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (ATCC).
TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Homozygous for TP53 p.Cys242Phe (c.725G>T) (ATCC).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.45
Native American0
East Asian, North1.54
East Asian, South0
South Asian1.1
European, North64.36
European, South32.54
Disease Medulloblastoma (NCIt: C3222)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D2S133816,17
D3S135815
D5S81811,13
D7S8208,10
D8S117913,15
D13S31713,14
D16S53910
D18S5112
D19S43314,14.2 (CCRID)
14.2 (PubMed=25877200)
D21S1129,31.2
FGA23
Penta D10,13
Penta E7,11
TH019
TPOX8,10
vWA14,20

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/DAOY_(biology)
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/d/cell-lines-detail-566.html
http://www.cellresource.cn/fdetail.aspx?id=218
Publications

PubMed=2993532; DOI=10.1097/00005072-198509000-00003
Jacobsen P.F., Jenkyn D.J., Papadimitriou J.M.
Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice.
J. Neuropathol. Exp. Neurol. 44:472-485(1985)

PubMed=1822845
Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=12973738; DOI=10.1002/pmic.200300460
Peyrl A., Krapfenbauer K., Slavc I., Yang J.-W., Strobel T., Lubec G.
Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.
Proteomics 3:1781-1800(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22723427; DOI=10.1093/neuonc/nos130
Sikkema A.H., den Dunnen W.F.A., Hulleman E., van Vuurden D.G., Garcia-Manero G., Yang H., Scherpen F.J.G., Kampen K.R., Hoving E.W., Kamps W.A., Diks S.H., Peppelenbosch M.P., de Bont E.S.J.M.
EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.
Neuro-oncol. 14:1125-1135(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281
Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

DOI=10.1016/j.euprot.2016.03.015
Martelli C., D'Angelo L., Barba M., Baranzini M., Inserra I., Iavarone F., Vincenzoni F., Tamburrini G., Massimi L., Di Rocco C., Caldarelli M., Messana I., Michetti F., Castagnola M., Lattanzi W., Desiderio C.
Top-down proteomic characterization of DAOY medulloblastoma tumor cell line.
EuPA Open Proteomics 12:13-21(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: Choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; HTB-186
BCRJ; 0325
NCBI_Iran; C519
Cell line databases/resources CCLE; DAOY_CENTRAL_NERVOUS_SYSTEM
CCRID; 3111C0001CCC000218
Cell_Model_Passport; SIDM00887
Cosmic-CLP; 906833
DepMap; ACH-000211
GDSC; 906833
LINCS_LDP; LCL-1576
Lonza; 1438
Ontologies BTO; BTO:0004328
CLO; CLO_0002699
EFO; EFO_0005698
Biological sample resources BioSample; SAMN03470909
BioSample; SAMN10988097
ENCODE; ENCBS055ILX
ENCODE; ENCBS812KQP
Chemistry resources ChEMBL-Cells; CHEMBL3308510
ChEMBL-Targets; CHEMBL612519
PharmacoDB; Daoy_282_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM482332
GEO; GSM886972
GEO; GSM888041
GEO; GSM919361
GEO; GSM1669725
GEO; GSM1938719
Other Wikidata; Q29511023
Polymorphism and mutation databases Cosmic; 687773
Cosmic; 906833
Cosmic; 923654
Cosmic; 973262
Cosmic; 974281
Cosmic; 975027
Cosmic; 1404441
Cosmic; 1995383
Cosmic; 2362649
IARC_TP53; 480
LiGeA; CCLE_339
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number26