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Cellosaurus DMS 153 (CVCL_1175)

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Cell line name DMS 153
Synonyms DMS-153; DMS153
Accession CVCL_1175
Resource Identification Initiative To cite this cell line use: DMS 153 (RRID:CVCL_1175)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 28 days (PubMed=6266631); 5.8 days (PubMed=2986244).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Thr155Pro (c.463A>C) (PubMed=14660794; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.64
Native American0.56
East Asian, North3.7
East Asian, South0
South Asian0
European, North51.44
European, South43.66
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_Z033 ! DMS 154
Sex of cell Male
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; ECACC; PubMed=25877200

Markers:
AmelogeninX (ATCC; CCRID)
X,Y (ECACC; PubMed=25877200)
CSF1PO10
D2S133817,20
D3S135817 (CCRID)
14,17 (PubMed=25877200)
D5S81812
D6S104311,18
D7S8208,10
D8S117912,14
D13S31713 (ATCC; CCRID; ECACC)
12,13 (PubMed=25877200)
D16S53912,13
D18S5116,17
D21S1126.2,30
FGA21
Penta D9,12
Penta E12 (CCRID)
12,13 (PubMed=25877200)
TH017,9.3
TPOX11
vWA14,15

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=907
http://www.cellresource.cn/fdetail.aspx?id=2016
Publications

PubMed=6266631; DOI=10.1002/1097-0142(19800301)45:5<906::AID-CNCR2820450513>3.0.CO;2-H
Pettengill O.S., Sorenson G.D., Wurster-Hill D.H., Curphey T.J., Noll W.W., Cate C.C., Maurer L.H.
Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.
Cancer 45:906-918(1980)

PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5
Vindelov L.L., Hansen H.H., Spang-Thomsen M.
Growth characteristics and heterogeneity of small cell carcinoma of the lung.
Recent Results Cancer Res. 97:47-54(1985)

PubMed=9744504; DOI=10.1038/bjc.1998.553
Damstrup L., Rude Voldborg B., Spang-Thomsen M., Brunner N., Skovgaard Poulsen H.
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Br. J. Cancer 78:631-640(1998)

PubMed=12712436; DOI=10.1002/ijc.11106
Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Int. J. Cancer 105:472-479(2003)

PubMed=14660794; DOI=10.1073/pnas.2536558100
Kanashiro C.A., Schally A.V., Groot K., Armatis P., Bernardino A.L.F., Varga J.L.
Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.
Proc. Natl. Acad. Sci. U.S.A. 100:15836-15841(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F., Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-2064
CCTCC; GDC0167
ECACC; 95062827
Cell line databases/resources CLDB; cl1078
CCLE; DMS153_LUNG
CCRID; 3111C0001CCC000397
CCRID; 3142C0001000000139
Cell_Model_Passport; SIDM01504
DepMap; ACH-000594
IGRhCellID; DMS153
LINCS_LDP; LCL-1831
Ontologies CLO; CLO_0002796
EFO; EFO_0002163
Biological sample resources BioSample; SAMN03471428
BioSample; SAMN03472954
BioSample; SAMN10988118
Chemistry resources ChEMBL-Cells; CHEMBL3308260
ChEMBL-Targets; CHEMBL2366167
GDSC; 687984
PharmacoDB; DMS153_298_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM827561
GEO; GSM886981
GEO; GSM888050
Other Wikidata; Q54831295
Polymorphism and mutation databases Cosmic; 687984
Cosmic; 2125220
Cosmic; 2648004
IARC_TP53; 19177
IARC_TP53; 21306
LiGeA; CCLE_646
Proteomic databases PRIDE; PXD011896
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number27