ID   DMS 53
AC   CVCL_1177
SY   DMS-53; DMS53
DR   BTO; BTO:0005668
DR   CLO; CLO_0002799
DR   EFO; EFO_0002165
DR   CLDB; cl1081
DR   AddexBio; C0016027/4988
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2062
DR   BioSample; SAMN03472957
DR   BioSample; SAMN10987596
DR   CCLE; DMS53_LUNG
DR   Cell_Model_Passport; SIDM00523
DR   ChEMBL-Cells; CHEMBL3308726
DR   ChEMBL-Targets; CHEMBL1075434
DR   Cosmic; 907295
DR   Cosmic; 1995386
DR   Cosmic; 2125221
DR   Cosmic; 2648008
DR   Cosmic-CLP; 907295
DR   DepMap; ACH-000698
DR   ECACC; 95062823
DR   GDSC; 907295
DR   GEO; GSM17307
DR   GEO; GSM169436
DR   GEO; GSM170721
DR   GEO; GSM170722
DR   GEO; GSM886984
DR   GEO; GSM888053
DR   GEO; GSM1669737
DR   IARC_TP53; 21308
DR   IGRhCellID; DMS53
DR   LiGeA; CCLE_721
DR   LINCS_LDP; LCL-1808
DR   PharmacoDB; DMS53_300_2019
DR   PRIDE; PXD011896
DR   Progenetix; CVCL_1177
DR   Wikidata; Q54831310
RX   PubMed=2986244;
RX   PubMed=6266631;
RX   PubMed=9744504;
RX   PubMed=12712436;
RX   PubMed=15016488;
RX   PubMed=17426248;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=22961666;
RX   PubMed=25485619;
RX   PubMed=25960936;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=DMS%2053
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Doubling time: 5.7 days (PubMed=6266631); 4.9 days (PubMed=2986244).
CC   HLA typing: A*03:01,01:01; B*35:03,08:01; C*04:01,07:01; DQA1*01:02,01:02; DQB1*06:02,06:02; DRB1*15:01,14:76 (PubMed=25960936).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu56Ter (c.166G>T); Zygosity=Heterozygous (CCLE; Cosmic-CLP).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=2.98%; Native American=0%; East Asian, North=4.32%; East Asian, South=0%; South Asian=0%; European, North=55.34%; European, South=37.36% (PubMed=30894373).
ST   Source(s): AddexBio; ATCC; Cosmic-CLP; ECACC; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10
ST   D16S539: 12,13
ST   D18S51: 15,16
ST   D21S11: 33.2
ST   D3S1358: 15
ST   D5S818: 10,11
ST   D7S820: 8,11
ST   D8S1179: 12
ST   FGA: 20
ST   Penta D: 10
ST   Penta E: 13
ST   TH01: 8,9.3
ST   TPOX: 12
ST   vWA: 15,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 32
//
RX   PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5;
RA   Vindelov L.L., Hansen H.H., Spang-Thomsen M.;
RT   "Growth characteristics and heterogeneity of small cell carcinoma of
RT   the lung.";
RL   Recent Results Cancer Res. 97:47-54(1985).
//
RX   PubMed=6266631; DOI=10.1002/1097-0142(19800301)45:5<906::AID-CNCR2820450513>3.0.CO;2-H;
RA   Pettengill O.S., Sorenson G.D., Wurster-Hill D.H., Curphey T.J.,
RA   Noll W.W., Cate C.C., Maurer L.H.;
RT   "Isolation and growth characteristics of continuous cell lines from
RT   small-cell carcinoma of the lung.";
RL   Cancer 45:906-918(1980).
//
RX   PubMed=9744504; DOI=10.1038/bjc.1998.553;
RA   Damstrup L., Rude Voldborg B., Spang-Thomsen M., Brunner N.,
RA   Skovgaard Poulsen H.;
RT   "In vitro invasion of small-cell lung cancer cell lines correlates
RT   with expression of epidermal growth factor receptor.";
RL   Br. J. Cancer 78:631-640(1998).
//
RX   PubMed=12712436; DOI=10.1002/ijc.11106;
RA   Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.;
RT   "The role of RAD51 in etoposide (VP16) resistance in small cell lung
RT   cancer.";
RL   Int. J. Cancer 105:472-479(2003).
//
RX   PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6;
RA   Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S.,
RA   Nakagawa K., Nomura H., Ishikawa Y.;
RT   "Two prognostically significant subtypes of high-grade lung
RT   neuroendocrine tumours independent of small-cell and large-cell
RT   neuroendocrine carcinomas identified by gene expression profiles.";
RL   Lancet 363:775-781(2004).
//
RX   PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367;
RA   Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K.,
RA   Sauter G., Lesniewski R., Semizarov D.;
RT   "Integrative genomic analysis of small-cell lung carcinoma reveals
RT   correlates of sensitivity to bcl-2 antagonists and uncovers novel
RT   chromosomal gains.";
RL   Mol. Cancer Res. 5:331-339(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112;
RA   Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P.,
RA   Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F.,
RA   Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J.,
RA   Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L.,
RA   Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D.,
RA   Heymach J.V.;
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//