Cellosaurus DOK (CVCL_1180)

Cell line name DOK
Synonyms Dysplastic Oral Keratinocyte
Accession CVCL_1180
Resource Identification Initiative To cite this cell line use: DOK (RRID:CVCL_1180)
Comments Microsatellite instability: Stable (MSS) (Sanger).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Oral dysplasia (NCIt: C129863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_2H27 (OSCC-BD)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D13S31711,13
D16S5399,12
D18S5112,15
D21S1129,31
D3S135817
D5S81812
D7S82011,13
D8S11799,15
FGA20,23
Penta D9,14
Penta E10,12
TH016,8
TPOX10
vWA14,18
Publications

PubMed=1459732; DOI=10.1002/ijc.2910520612
Chang S.E., Foster S., Betts D., Marnock W.E.
DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype.
Int. J. Cancer 52:896-902(1992)

PubMed=25169794; DOI=10.1111/jop.12236
Dickman C.T.D., Towle R., Saini R., Garnis C.
Molecular characterization of immortalized normal and dysplastic oral cell lines.
J. Oral Pathol. Med. 44:329-336(2015)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26234610; DOI=10.1038/srep12668
Dong Y., Zhao Q., Ma X.-Y., Ma G.-W., Liu C.-Y., Chen Z.-W., Yu L.-Y., Liu X.-F., Zhang Y.-G., Shao S.-J., Xiao J., Li J., Zhang W.-M., Fu M., Dong L.-J., Yang X.-D., Guo X., Xue L.-Y., Fang F., Zhan Q.-M., Zhang L.-H.
Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.
Sci. Rep. 5:12668-12668(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ECACC; 94122104
Ximbio; 153251
Cell line databases/resources CLDB; cl1087
Cosmic-CLP; 910936
GDSC; 910936
Ontologies CLO; CLO_0002806
EFO; EFO_0006564
Biological sample resources BioSample; SAMN03473147
Chemistry resources ChEMBL-Cells; CHEMBL3308727
ChEMBL-Targets; CHEMBL1075435
Gene expression databases GEO; GSM827453
GEO; GSM1374468
GEO; GSM1431134
GEO; GSM1669741
Polymorphism and mutation databases Cosmic; 910936
Cosmic; 1339915