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Cellosaurus DOK (CVCL_1180)

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Cell line name DOK
Synonyms Dysplastic Oral Keratinocyte
Accession CVCL_1180
Resource Identification Initiative To cite this cell line use: DOK (RRID:CVCL_1180)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Doubling time: ~40 hours (PubMed=1459732).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Oral cavity; tongue. Cell type=Keratinocyte.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu188_Pro191del (c.563_574del12); Zygosity=Unspecified (PubMed=7917902).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.7
East Asian, North2.72
East Asian, South0
South Asian0
European, North66.66
European, South29.51
Disease Oral epithelial dysplasia (NCIt: C129863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=25877200

Penta D9,14
Penta E10,12

Run an STR similarity search on this cell line

PubMed=1459732; DOI=10.1002/ijc.2910520612
Chang S.E., Foster S., Betts D., Marnock W.E.
DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype.
Int. J. Cancer 52:896-902(1992)

PubMed=7917902; DOI=10.1038/bjc.1994.356
Burns J.E., Clark L.J., Yeudall W.A., Mitchell R., Mackenzie K., Chang S.E., Parkinson E.K.
The p53 status of cultured human premalignant oral keratinocytes.
Br. J. Cancer 70:591-595(1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25169794; DOI=10.1111/jop.12236
Dickman C.T.D., Towle R., Saini R., Garnis C.
Molecular characterization of immortalized normal and dysplastic oral cell lines.
J. Oral Pathol. Med. 44:329-336(2015)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26234610; DOI=10.1038/srep12668
Dong Y., Zhao Q., Ma X.-Y., Ma G.-W., Liu C.-Y., Chen Z.-W., Yu L.-Y., Liu X.-F., Zhang Y.-G., Shao S.-J., Xiao J., Li J., Zhang W.-M., Fu M., Dong L.-J., Yang X.-D., Guo X., Xue L.-Y., Fang F., Zhan Q.-M., Zhang L.-H.
Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.
Sci. Rep. 5:12668-12668(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ECACC; 94122104
Ximbio; 153251
Cell line databases/resources CLO; CLO_0002806
CLDB; cl1087
Cell_Model_Passport; SIDM00540
Cosmic-CLP; 910936
DepMap; ACH-002234
Biological sample resources BioSample; SAMN03473147
Chemistry resources ChEMBL-Cells; CHEMBL3308727
ChEMBL-Targets; CHEMBL1075435
GDSC; 910936
PharmacoDB; DOK_304_2019
Encyclopedic resources Wikidata; Q54831351
Experimental variables resources EFO; EFO_0006564
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM827453
GEO; GSM1374468
GEO; GSM1431134
GEO; GSM1669741
Polymorphism and mutation databases Cosmic; 910936
Cosmic; 1339915
IARC_TP53; 21311
Progenetix; CVCL_1180
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number30