ID   DOK
AC   CVCL_1180
SY   Dysplastic Oral Keratinocyte
DR   CLO; CLO_0002806
DR   EFO; EFO_0006564
DR   CLDB; cl1087
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473147
DR   Cell_Model_Passport; SIDM00540
DR   ChEMBL-Cells; CHEMBL3308727
DR   ChEMBL-Targets; CHEMBL1075435
DR   Cosmic; 910936
DR   Cosmic; 1339915
DR   Cosmic-CLP; 910936
DR   DepMap; ACH-002234
DR   ECACC; 94122104
DR   EGA; EGAS00001000978
DR   GDSC; 910936
DR   GEO; GSM827453
DR   GEO; GSM1374468
DR   GEO; GSM1431134
DR   GEO; GSM1669741
DR   IARC_TP53; 21311
DR   PharmacoDB; DOK_304_2019
DR   Progenetix; CVCL_1180
DR   Wikidata; Q54831351
DR   Ximbio; 153251
RX   PubMed=1459732;
RX   PubMed=7917902;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=25169794;
RX   PubMed=25485619;
RX   PubMed=26234610;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Doubling time: ~40 hours (PubMed=1459732).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Leu188_Pro191del (c.563_574del12); Zygosity=Unspecified (PubMed=7917902).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.41%; Native American=0.7%; East Asian, North=2.72%; East Asian, South=0%; South Asian=0%; European, North=66.66%; European, South=29.51% (PubMed=30894373).
CC   Derived from sampling site: Oral cavity; tongue. Cell type=Keratinocyte.
ST   Source(s): Cosmic-CLP; ECACC; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11,13
ST   D16S539: 9,12
ST   D18S51: 12,15
ST   D21S11: 29,31
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 11,13
ST   D8S1179: 9,15
ST   FGA: 20,23
ST   Penta D: 9,14
ST   Penta E: 10,12
ST   TH01: 6,8
ST   TPOX: 10
ST   vWA: 14,18
DI   NCIt; C129863; Oral epithelial dysplasia
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 16-12-21; Version: 30
//
RX   PubMed=1459732; DOI=10.1002/ijc.2910520612;
RA   Chang S.E., Foster S., Betts D., Marnock W.E.;
RT   "DOK, a cell line established from human dysplastic oral mucosa, shows
RT   a partially transformed non-malignant phenotype.";
RL   Int. J. Cancer 52:896-902(1992).
//
RX   PubMed=7917902; DOI=10.1038/bjc.1994.356;
RA   Burns J.E., Clark L.J., Yeudall W.A., Mitchell R., Mackenzie K.,
RA   Chang S.E., Parkinson E.K.;
RT   "The p53 status of cultured human premalignant oral keratinocytes.";
RL   Br. J. Cancer 70:591-595(1994).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=25169794; DOI=10.1111/jop.12236;
RA   Dickman C.T.D., Towle R., Saini R., Garnis C.;
RT   "Molecular characterization of immortalized normal and dysplastic oral
RT   cell lines.";
RL   J. Oral Pathol. Med. 44:329-336(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=26234610; DOI=10.1038/srep12668;
RA   Dong Y., Zhao Q., Ma X.-Y., Ma G.-W., Liu C.-Y., Chen Z.-W., Yu L.-Y.,
RA   Liu X.-F., Zhang Y.-G., Shao S.-J., Xiao J., Li J., Zhang W.-M., Fu M.,
RA   Dong L.-J., Yang X.-D., Guo X., Xue L.-Y., Fang F., Zhan Q.-M.,
RA   Zhang L.-H.;
RT   "Establishment of a new OSCC cell line derived from OLK and
RT   identification of malignant transformation-related proteins by
RT   differential proteomics approach.";
RL   Sci. Rep. 5:12668-12668(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//