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Cellosaurus DV-90 (CVCL_1184)

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Cell line name DV-90
Synonyms DV90
Accession CVCL_1184
Resource Identification Initiative To cite this cell line use: DV-90 (RRID:CVCL_1184)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 24 hours (PubMed=7839470); ~95 hours (DSMZ).
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for KRAS p.Gly13Asp (c.38G>A) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.68
Native American0
East Asian, North2.16
East Asian, South0
South Asian3.04
European, North41.86
European, South52.26
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LM80 (DV-90-GFP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D3S135813,16
D5S81811,13
D7S82011,14
D8S117914,16
D13S31710,12
D16S53911,12
D18S5113,14
D21S1131,31.2
FGA22,24
Penta D9,10
Penta E10,13
TH017,8
TPOX8
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=7839470
Monti F., Szymczuk S., Chessa L., Prudente S., Nicoletti G., Fattori P.P., Pini E., Desiderio F., Pasquini E., Tison V., Ravaioli A.
Biologic characterization of pleural metastases from lung adenocarcinoma: description of the new DV90 cell line.
Tumori 80:378-384(1994)

PubMed=10908148; DOI=10.1038/labinvest.3780108
Speicher M.R., Petersen S., Uhrig S., Jentsch I., Fauth C., Eils R., Petersen I.
Analysis of chromosomal alterations in non-small cell lung cancer by multiplex-FISH, comparative genomic hybridization, and multicolor bar coding.
Lab. Invest. 80:1031-1041(2000)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003
Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C., Daub H.
Comparative proteome analysis across non-small cell lung cancer cell lines.
J. Proteomics 130:1-10(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-307
Cell line databases/resources CCLE; DV90_LUNG
Cell_Model_Passport; SIDM01510
DepMap; ACH-000925
GDSC; 753553
IGRhCellID; DV-90_02GEO
LINCS_LDP; LCL-1636
Ontologies CLO; CLO_0002847
EFO; EFO_0006565
Biological sample resources BioSample; SAMN03473076
BioSample; SAMN10988133
Chemistry resources ChEMBL-Cells; CHEMBL3308729
ChEMBL-Targets; CHEMBL1075437
PharmacoDB; DV90_311_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM434301
GEO; GSM784284
GEO; GSM886990
GEO; GSM888059
Other Wikidata; Q54831597
Polymorphism and mutation databases Cosmic; 753553
Cosmic; 1146951
LiGeA; CCLE_820
Proteomic databases PRIDE; PXD002556
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number25