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Cellosaurus ES1 (CVCL_1198)

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Cell line name ES1
Synonyms ES-1
Accession CVCL_1198
Resource Identification Initiative To cite this cell line use: ES1 (RRID:CVCL_1198)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (PubMed=25010205).
TP53 p.Arg248Gln (c.743G>A) (PubMed=25010205).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.83
Native American0.47
East Asian, North0.13
East Asian, South0
South Asian0.81
European, North70.63
European, South27.13
Disease Ewing sarcoma (NCIt: C4817)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=25010205

Markers:
AmelogeninX
CSF1PO10
D2S133823,25
D3S135814,16
D5S81811
D7S8209,12
D8S117913
D13S3179,11
D16S53911
D18S5119
D19S43315,15.2
D21S1129,30
FGA21,23
TH019.3,10
TPOX10
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H., Wen X., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; ES1_BONE
Cell_Model_Passport; SIDM00266
Cosmic-CLP; 949158
DepMap; ACH-002103
GDSC; 949158
LINCS_LDP; LCL-1439
Chemistry resources ChEMBL-Cells; CHEMBL3308820
ChEMBL-Targets; CHEMBL2366146
PharmacoDB; ES1_338_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669768
GEO; GSM1676361
GEO; GSM1701628
Other Wikidata; Q54832633
Polymorphism and mutation databases Cosmic; 684053
Cosmic; 949158
Cosmic; 1995395
Cosmic; 2228222
IARC_TP53; 27154
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23