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Cellosaurus ES4 (CVCL_1200)

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Cell line name ES4
Synonyms ES-4
Accession CVCL_1200
Resource Identification Initiative To cite this cell line use: ES4 (RRID:CVCL_1200)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (PubMed=25010205).
PIK3CA p.Gly118Asp (c.353G>A) (PubMed=25010205).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.29
Native American7.84
East Asian, North0
East Asian, South1.09
South Asian1.81
European, North61.75
European, South26.22
Disease Ewing sarcoma (NCIt: C4817)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO11
D2S133817,20
D3S135816,17
D5S81811,12
D7S82011,12
D8S117913,14
D13S31711,12
D16S5399
D18S5116,18
D19S43312,15
D21S1129
FGA20,25
TH016,7
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H., Wen X., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; ES4_BONE
Cell_Model_Passport; SIDM00264
Cosmic-CLP; 949156
DepMap; ACH-002105
GDSC; 949156
LINCS_LDP; LCL-1441
Chemistry resources ChEMBL-Cells; CHEMBL3308151
ChEMBL-Targets; CHEMBL2366118
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669771
GEO; GSM1676340
GEO; GSM1676369
GEO; GSM1701630
GEO; GSM1701671
GEO; GSM1701698
Other Wikidata; Q54832637
Polymorphism and mutation databases Cosmic; 684056
Cosmic; 949156
Cosmic; 2228224
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number22