Cellosaurus ES8 (CVCL_1204)

Cell line name ES8
Synonyms ES-8
Accession CVCL_1204
Resource Identification Initiative To cite this cell line use: ES8 (RRID:CVCL_1204)
Comments Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (PubMed=25010205).
TP53 p.Cys135Phe (c.404G>T) (PubMed=25010205).
Disease Ewing sarcoma (NCIt: C4817)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO10,13
D13S31713
D16S53911
D18S5115,17
D19S43313,14
D21S1129,33.2
D2S133818
D3S135816
D5S81812,13
D7S8207,12
D8S117912,14
FGA18,23
TH016,9.3
TPOX8,9
vWA16,17
Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H., Wen X., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line databases/resources Cosmic-CLP; 949155
GDSC; 949155
LINCS_LDP; LCL-1445
Chemistry resources ChEMBL-Cells; CHEMBL3308153
ChEMBL-Targets; CHEMBL2366069
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669775
GEO; GSM1676297
GEO; GSM1701632
Other Wikidata; Q54832645
Polymorphism and mutation databases Cosmic; 684060
Cosmic; 949155
Cosmic; 1995399
Cosmic; 2060799
Cosmic; 2228227