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Cellosaurus ES8 (CVCL_1204)

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Cell line name ES8
Synonyms ES-8
Accession CVCL_1204
Resource Identification Initiative To cite this cell line use: ES8 (RRID:CVCL_1204)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (PubMed=25010205).
Homozygous for TP53 p.Cys135Phe (c.404G>T) (PubMed=25010205; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.48
Native American0.07
East Asian, North0.25
East Asian, South1.89
South Asian9.11
European, North26.16
European, South61.04
Disease Ewing sarcoma (NCIt: C4817)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO10,13
D2S133818
D3S135816
D5S81812,13
D7S8207,12
D8S117912,14
D13S31713
D16S53911
D18S5115,17
D19S43313,14
D21S1129,33.2
FGA18,23
TH016,9.3
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H., Wen X., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; ES8_BONE
Cell_Model_Passport; SIDM00261
Cosmic-CLP; 949155
DepMap; ACH-002109
GDSC; 949155
LINCS_LDP; LCL-1445
Chemistry resources ChEMBL-Cells; CHEMBL3308153
ChEMBL-Targets; CHEMBL2366069
PharmacoDB; ES8_344_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669775
GEO; GSM1676297
GEO; GSM1701632
Other Wikidata; Q54832645
Polymorphism and mutation databases Cosmic; 684060
Cosmic; 949155
Cosmic; 1995399
Cosmic; 2060799
Cosmic; 2228227
IARC_TP53; 27160
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24