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Cellosaurus ETK-1 (CVCL_1206)

Cell line name ETK-1
Synonyms ETK1
Accession CVCL_1206
Resource Identification Initiative To cite this cell line use: ETK-1 (RRID:CVCL_1206)
Comments Problematic cell line: Contaminated. Shown to be a SSP-25 derivative (PubMed=16643607; PubMed=20143388). Originally thought to originate from the ascitic fluid of a 61 year old woman patient with sarcomatoid cholangiocarcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00196.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4902 (SSP-25)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx

PubMed=9252136; DOI=10.1002/hep.510260206
Enjoji M., Nakashima M., Honda M., Sakai H., Nawata H.
Hepatocytic phenotypes induced in sarcomatous cholangiocarcinoma cells treated with 5-azacytidine.
Hepatology 26:288-294(1997)

PubMed=10761710; DOI=10.1111/j.1349-7006.2000.tb00935.x
Enjoji M., Nakashima M., Nakamuta M., Nawata H.
Transforming growth factor-alpha induces the differentiation of sarcomatoid cholangiocarcinoma cells.
Jpn. J. Cancer Res. 91:223-230(2000)

PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x
Yoshino K., Iimura E., Saijo K., Iwase S., Fukami K., Ohno T., Obata Y., Nakamura Y.
Essential role for gene profiling analysis in the authentication of human cell lines.
Hum. Cell 19:43-48(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections RCB; RCB1289 - Discontinued
Cell line databases/resources CCLE; ETK1_BILIARY_TRACT
Cosmic-CLP; 906861
GDSC; 906861
Biological sample resources BioSample; SAMN03151925
Chemistry resources ChEMBL-Cells; CHEMBL3308831
ChEMBL-Targets; CHEMBL2366116
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669779
Other Wikidata; Q54832847
Polymorphism and mutation databases Cosmic; 906861