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Cellosaurus EW-11 (CVCL_1209)

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Cell line name EW-11
Synonyms EW11; IARC-EW11; IARC-EW-11; IARC-EW 11
Accession CVCL_1209
Resource Identification Initiative To cite this cell line use: EW-11 (RRID:CVCL_1209)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Arg273Cys (c.817C>T) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African20.84
Native American0.67
East Asian, North0
East Asian, South2.32
South Asian4.42
European, North15.83
European, South55.92
Disease Ewing sarcoma (NCIt: C4817)
Derived from metastatic site: Mediastinal lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO11,13
D5S81812
D7S82010,11
D13S31711,12
D16S53912
TH019.3
TPOX8,9
vWA15,19

Run an STR similarity search on this cell line
Publications

PubMed=6713356; DOI=10.1016/0165-4608(84)90002-5
Turc-Carel C., Philip I., Berger M.-P., Philip T., Lenoir G.M.
Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).
Cancer Genet. Cytogenet. 12:1-19(1984)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; EW11_BONE
Cell_Model_Passport; SIDM00203
Cosmic-CLP; 684062
DepMap; ACH-002111
GDSC; 684062
LINCS_LDP; LCL-1447
Chemistry resources ChEMBL-Cells; CHEMBL3308193
ChEMBL-Targets; CHEMBL2366223
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669782
Other Wikidata; Q54832990
Polymorphism and mutation databases Cosmic; 684062
Cosmic; 965554
Cosmic; 1084592
IARC_TP53; 27162
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number21