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Cellosaurus EW-3 (CVCL_1216)

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Cell line name EW-3
Synonyms EW3; IARC-EW3; IARC-EW-3; IARC-EW 3
Accession CVCL_1216
Resource Identification Initiative To cite this cell line use: EW-3 (RRID:CVCL_1216)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations EWSR1-ERG (EWS-ERG) gene fusion (PubMed=16631476).
STAG2 p.Arg216Ter (c.646C>T) (PubMed=25223734).
TP53 c.852_858del7 (PubMed=19787792).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.33
East Asian, North0.83
East Asian, South0.4
South Asian6.18
European, North47.05
European, South45.2
Disease Ewing sarcoma (NCIt: C4817)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=19787792

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133820,22
D3S135816
D5S81812
D7S8208,11
D8S117912,14
D13S31712
D16S53911,12
D18S5116,18
D19S43313,15
D21S1129,31.2
FGA22,25
SE3315.3,16
TH019.3,10
TPOX8,9
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=6713356; DOI=10.1016/0165-4608(84)90002-5
Turc-Carel C., Philip I., Berger M.-P., Philip T., Lenoir G.M.
Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).
Cancer Genet. Cytogenet. 12:1-19(1984)

PubMed=11423975; DOI=10.1038/sj.onc.1204437
Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V., Weissman B.E., Delattre O.
Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression.
Oncogene 20:3258-3265(2001)

PubMed=16631476; DOI=10.1016/j.cancergencyto.2005.11.006
Szuhai K., Ijszenga M., Tanke H.J., Rosenberg C., Hogendoorn P.C.W.
Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines.
Cancer Genet. Cytogenet. 166:173-179(2006)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622
Tirode F., Surdez D., Ma X., Parker M., Le Deley M.C., Bahrami A., Zhang Z., Lapouble E., Grossetete-Lalami S., Rusch M., Reynaud S., Rio-Frio T., Hedlund E., Wu G., Chen X., Pierron G., Oberlin O., Zaidi S., Lemmon G., Gupta P., Vadodaria B., Easton J., Gut M., Ding L., Mardis E.R., Wilson R.K., Shurtleff S., Laurence V., Michon J., Marec-Berard P., Gut I.G., Downing J., Dyer M., Zhang J., Delattre O.
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Cancer Discov. 4:1342-1353(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; EW3_BONE
Cell_Model_Passport; SIDM00202
Cosmic-CLP; 949161
DepMap; ACH-002118
GDSC; 949161
LINCS_LDP; LCL-1452
Chemistry resources ChEMBL-Cells; CHEMBL3308521
ChEMBL-Targets; CHEMBL2366307
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM510005
GEO; GSM1669789
Other Wikidata; Q54833002
Polymorphism and mutation databases Cosmic; 684070
Cosmic; 949161
Cosmic; 1995405
Cosmic; 2250460
IARC_TP53; 27038
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number22