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Cellosaurus EW-7 (CVCL_1217)

[Text version]

Cell line name EW-7
Synonyms EW7; IARC-EW7; IARC-EW-7; IARC-EW 7
Accession CVCL_1217
Resource Identification Initiative To cite this cell line use: EW-7 (RRID:CVCL_1217)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations EWSR1-FLI1 (EWS-FLI1) gene fusion (PubMed=16631476).
CDKN2A deletion (PubMed=25223734).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.24
Native American0
East Asian, North0
East Asian, South0
South Asian3.39
European, North57.71
European, South38.66
Disease Ewing sarcoma (NCIt: C4817)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 20Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO12
D5S81810,13
D7S8209
D13S3178
D16S53912
TH016
TPOX8,9
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=6713356; DOI=10.1016/0165-4608(84)90002-5
Turc-Carel C., Philip I., Berger M.-P., Philip T., Lenoir G.M.
Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).
Cancer Genet. Cytogenet. 12:1-19(1984)

PubMed=11423975; DOI=10.1038/sj.onc.1204437
Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V., Weissman B.E., Delattre O.
Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression.
Oncogene 20:3258-3265(2001)

PubMed=16631476; DOI=10.1016/j.cancergencyto.2005.11.006
Szuhai K., Ijszenga M., Tanke H.J., Rosenberg C., Hogendoorn P.C.W.
Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines.
Cancer Genet. Cytogenet. 166:173-179(2006)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622
Tirode F., Surdez D., Ma X., Parker M., Le Deley M.C., Bahrami A., Zhang Z., Lapouble E., Grossetete-Lalami S., Rusch M., Reynaud S., Rio-Frio T., Hedlund E., Wu G., Chen X., Pierron G., Oberlin O., Zaidi S., Lemmon G., Gupta P., Vadodaria B., Easton J., Gut M., Ding L., Mardis E.R., Wilson R.K., Shurtleff S., Laurence V., Michon J., Marec-Berard P., Gut I.G., Downing J., Dyer M., Zhang J., Delattre O.
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Cancer Discov. 4:1342-1353(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; EW7_BONE
Cell_Model_Passport; SIDM00201
Cosmic-CLP; 949160
DepMap; ACH-002119
GDSC; 949160
LINCS_LDP; LCL-1453
Chemistry resources ChEMBL-Cells; CHEMBL3308165
ChEMBL-Targets; CHEMBL2366112
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669790
Other Wikidata; Q54833003
Polymorphism and mutation databases Cosmic; 684071
Cosmic; 949160
Cosmic; 1995406
Cosmic; 2250471
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number22