ID   EW-7
AC   CVCL_1217
SY   EW7; IARC-EW7; IARC-EW-7; IARC-EW 7
DR   ArrayExpress; E-MTAB-3610
DR   CCLE; EW7_BONE
DR   Cell_Model_Passport; SIDM00201
DR   ChEMBL-Cells; CHEMBL3308165
DR   ChEMBL-Targets; CHEMBL2366112
DR   Cosmic; 684071
DR   Cosmic; 949160
DR   Cosmic; 1995406
DR   Cosmic; 2250471
DR   Cosmic-CLP; 949160
DR   DepMap; ACH-002119
DR   GDSC; 949160
DR   GEO; GSM1669790
DR   LINCS_LDP; LCL-1453
DR   Wikidata; Q54833003
RX   PubMed=6713356;
RX   PubMed=11423975;
RX   PubMed=16631476;
RX   PubMed=20164919;
RX   PubMed=25223734;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: EWSR1-FLI1 (EWS-FLI1) gene fusion (PubMed=16631476).
CC   Sequence variation: CDKN2A deletion (PubMed=25223734).
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.24%; Native American=0%; East Asian, North=0%; East Asian, South=0%; South Asian=3.39%; European, North=57.71%; European, South=38.66% (PubMed=30894373).
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): Cosmic-CLP
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8
ST   D16S539: 12
ST   D5S818: 10,13
ST   D7S820: 9
ST   TH01: 6
ST   TPOX: 8,9
ST   vWA: 16,18
DI   NCIt; C4817; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   20Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-07-19; Version: 22
//
RX   PubMed=6713356; DOI=10.1016/0165-4608(84)90002-5;
RA   Turc-Carel C., Philip I., Berger M.-P., Philip T., Lenoir G.M.;
RT   "Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a
RT   reciprocal translocation t(11;22)(q24;q12).";
RL   Cancer Genet. Cytogenet. 12:1-19(1984).
//
RX   PubMed=11423975; DOI=10.1038/sj.onc.1204437;
RA   Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V.,
RA   Weissman B.E., Delattre O.;
RT   "Analysis of the expression of cell cycle regulators in Ewing cell
RT   lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression.";
RL   Oncogene 20:3258-3265(2001).
//
RX   PubMed=16631476; DOI=10.1016/j.cancergencyto.2005.11.006;
RA   Szuhai K., Ijszenga M., Tanke H.J., Rosenberg C., Hogendoorn P.C.W.;
RT   "Molecular cytogenetic characterization of four previously established
RT   and two newly established Ewing sarcoma cell lines.";
RL   Cancer Genet. Cytogenet. 166:173-179(2006).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622;
RA   Tirode F., Surdez D., Ma X., Parker M., Le Deley M.C., Bahrami A.,
RA   Zhang Z., Lapouble E., Grossetete-Lalami S., Rusch M., Reynaud S.,
RA   Rio-Frio T., Hedlund E., Wu G., Chen X., Pierron G., Oberlin O.,
RA   Zaidi S., Lemmon G., Gupta P., Vadodaria B., Easton J., Gut M.,
RA   Ding L., Mardis E.R., Wilson R.K., Shurtleff S., Laurence V.,
RA   Michon J., Marec-Berard P., Gut I.G., Downing J., Dyer M., Zhang J.,
RA   Delattre O.;
RT   "Genomic landscape of Ewing sarcoma defines an aggressive subtype with
RT   co-association of STAG2 and TP53 mutations.";
RL   Cancer Discov. 4:1342-1353(2014).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//